cell proliferation, cell cycle arrest and induction of apoptosis were investigated, using three human head and neck squamous cell carcinoma (HNSCC) cell lines (OSCC-3, SCC-61, and SQ-20B). Aqueous extracts of , , and were tested and (-) epigallocatechin-3-gallate (EGCG) was used for comparison. For EGCG the IC values were between 80 and 166 μM and for the extracts among 75 and 505 μM eq. (+) catechin, with demonstrating dominant cytotoxicity. There was not a correlation between antioxidant capacity and cytotoxicity. Flow cytometry analysis revealed similarities in response for EGCG and . The extract altered DNA distribution ( < 0.05) and was the most effective in induction of apoptosis caspases ( < 0.05). Not all HNSCC cells tested responded to the same preventive agents. The fact that inhibits HNSCC cell proliferation makes this aqueous extract a potential source of chemopreventive agents.
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| http://dx.doi.org/10.1016/j.toxrep.2016.01.013 | DOI Listing |
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