Background: To analyze protective/regenerative effects of adipose tissue-derived mesenchymal stem cells (ADMSC) on I-Radioiodine (RAI)-induced salivary gland damage in rats.
Materials And Methods: Study population consisted of controls (n:6) and study groups (n:54): RAI (Group 1), ADMSC (Group 2), amifostine (Group 3), RAI+amifostine (Group 4), concomitant RAI+ADMSC (Group 5) and RAI+ADMSC after 48 h (Group 6). We used light microscopy (LM), transmission electron microscopy (TEM), and salivary gland scintigraphy (SGS), and analyzed data statistically.
Results: We observed the homing of ADMSC in salivary glands at 1 month on LM. RAI exposure affected necrosis, periductal fibrosis, periductal sclerosis, vascular sclerosis and the total sum score were in a statistically significant manner ( < 0.05). Intragroup comparisons with LM at 1 and 6 months revealed statistically significant improvements in Group 6 ( < 0.05) but not in Groups 4 and 5. Intergroup comparisons of the total score showed that Groups 4 and 5 in 1 month and Group 6 in 6 month had the lowest values. TEM showed vacuolization, edema, and fibrosis at 1 month, and an improvement in damage in 6 month in Groups 5 and 6. SGSs revealed significant differences for the maximum secretion ratio (Smax) ( = 0.01) and the gland-to-background ratio at a maximum count (G/BGmax) ( = 0. 01) at 1 month, for G/BGmax ( = 0.01), Smax ( = 0.01) and the time to reach the maximum count ratio over the time to reach the minimum count (Tmax/Tmin) ( = 0.03) at 6 month. 1 and 6 month scans showed differences for Smax and G/BGmax ( = 0.04), but not for Tmax/Tmin ( > 0.05). We observed a significant deterioration in gland function in group 1, whereas, mild to moderate deteriorations were seen in protective treatment groups.
Conclusions: Our results indicated that ADMSC might play a promising role as a protective/regenerative agent against RAI-induced salivary gland dysfunction.
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| http://dx.doi.org/10.1515/raon-2017-0022 | DOI Listing |
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