AI Article Synopsis
- A study investigated the significance of acute histological activity (AHA) in predicting clinical relapse (CR) among ulcerative colitis (UC) patients who were in remission.
- The research included 113 patients who had left-sided or extensive UC and were undergoing colonoscopies from 2005 to 2015, assessing their biopsy samples for inflammatory activity.
- Findings indicated that the presence of AHA, especially when combined with a flare in the past year, was a significant risk factor for relapse, highlighting the importance of histological evaluation in managing UC.
Article Abstract
Background: It has been suggested that acute histological activity has a prognostic value in the outcome of ulcerative colitis (UC) patients in clinical and endoscopic remission. Our aim was to assess the role of histology as a risk factor for clinical relapse (CR) in patients in both clinical and endoscopic remission.
Methods: Patients with left-sided or extensive UC in clinical and endoscopic remission (Mayo endoscopic subscore ≤1) undergoing colonoscopy for dysplasia surveillance with random colonic biopsies between 2005-2015 were included. Basal plasmacytosis, acute (AHA), and the chronic (CHA) histological inflammatory activity of all biopsy sets were evaluated.
Results: One hundred and thirteen patients were included. Median time in clinical remission at inclusion was 27 months (IQR 15-56). Eight percent of patients relapsed within the first year and 33% during the whole follow-up period. In the univariate analysis, the presence of AHA, alone (P=0.048) or together with a past flare within the previous 12 months (P=0.01), was associated with CR within the first year of follow-up. In the multivariate analysis, AHA, together with a flare within the previous 12 months, remained the only risk factor for relapse (RR=7.5; IC95%; 1.8-29.9; P=0.005).
Conclusions: In UC patients in clinical and endoscopic remission, the presence of AHA is a risk factor for clinical relapse.
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| http://dx.doi.org/10.1016/j.dld.2017.08.041 | DOI Listing |
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