AI Article Synopsis
- The study investigates the anti-inflammatory properties of Euphorbia supina (ES) ethanol extract on colitis induced by dextran sulfate sodium (DSS).
- Administering 20 mg/kg of ES significantly mitigates symptoms such as weight loss and colon shortening, while also improving disease activity scores and enzyme levels.
- Histological analysis reveals that ES reduces tissue damage and inflammation markers in the colon, suggesting its potential for treating ulcerative colitis.
Article Abstract
The aim of this study is to examine the anti-inflammatory effect of Euphorbia supina (ES) ethanol extract in dextran sulfate sodium (DSS)-induced experimental colitis model. ES was per orally administered at different doses of 4 or 20 mg/kg body weight with 5% DSS in drinking water for 7 days. Twenty mg/kg of ES administration regulated body weight decrease, recovered colon length shortening, and increased disease activity index score and myeloperoxidase level in DSS-induced colitis. Histological features showed that 20 mg/kg of ES administration suppressed edema, mucosal damage, and the loss of crypts induced by DSS. Furthermore, ES suppressed the expressions of COX-2, iNOS, NF-kB, IkBα, pIkBα in colon tissue. These findings demonstrated a possible effect of amelioration of ulcerative colitis and could be clinically applied.
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| http://dx.doi.org/10.1080/09168451.2017.1373590 | DOI Listing |
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Article Synopsis
- Eleven new diterpenoid lactones were isolated from Euphorbia peplus, along with nine previously known compounds, using advanced techniques to determine their structures and configurations.* -
- The anti-inflammatory effects of these compounds were tested on macrophages, with several (specifically compounds 6-9 and 12-19) significantly decreasing nitric oxide production and mRNA expression of inflammatory markers IL-6, IL-1β, and TNFα.* -
- Compound 6 showed particularly strong results, indicating potential for treating inflammation-related diseases due to its ability to inhibit inflammatory mediators and specific signaling pathways.*
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