Background: Recurrent abdominal pain (RAP) in childhood is common, with no explanatory pathology identified in the majority of cases. Previous studies have consistently demonstrated an association between childhood RAP and later emotional distress disorders. The aim of this study was to replicate this finding through the analysis of a large dataset, and explore how a negative style of thinking could potentially influence this relationship.
Methods: The Avon Longitudinal Study of Parents and Children (ALSPAC) is a population cohort of children born in the Avon area of the UK, between 1991-1992. Data on childhood RAP was collected via maternal reports at 3, 4, 7 and 9 years. Mood, anxiety and cognitive style were measured at age 18. We controlled for various confounding factors, including maternal anxiety and the child's pre-existing psychopathology. Logistic regression models were used to examine associations, and moderation effects of cognitive style were analysed using likelihood ratios.
Results: Experiencing RAP at any one time-point is associated with an increased odds of depression and/or anxiety disorder at 18 (OR = 1.41, 95% CI 1.09-1.83). We found a dose-response relationship and each additional marker of RAP was associated with a 26% (CI: 7% to 47%) increase in risk of having a mood and/or anxiety disorder. Individuals who attribute adversity to global, stable or personal factors were at amplified risk.
Conclusions: Childhood RAP predicts depression and anxiety disorders at 18 and should be targeted for early intervention. Individuals with a negative cognitive style may be particularly vulnerable, suggesting that cognitive interpretations of physical symptoms could play an important role in long-term health outcomes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619817 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185643 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Does music counteract mental fatigue? A systematic review.
PLoS One
January 2025
Department of Sport Studies, Faculty of Education Studies, Universiti Putra Malaysia, Selangor, Malaysia.
Article Synopsis
- Mental fatigue is a state caused by prolonged cognitive tasks that negatively affects both mental and physical performance, leading to the need for effective countermeasures.
- Music, being noninvasive and portable, is proposed as a potential solution to combat mental fatigue, although effectiveness can vary by music style.
- A systematic review of nine studies found that relaxing, exciting, and personally preferred music can reduce feelings of mental fatigue and enhance cognitive performance, particularly in tasks involving inhibition and working memory.
Clinical Manifestations.
Alzheimers Dement
December 2024
Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.
Background: Lifetime risk for symptomatic Alzheimer's disease (AD) in people with Down syndrome (DS) is 90%, with the age of onset of symptomatic AD ranging widely. Identifying resiliency factors related to a later age of symptoms is of critical importance for the DS community. This study investigated lifestyle factors hypothesized to moderate the association between amyloid-beta (Aβ plaques) and AD symptoms in adults with DS.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
University of California, San Diego, La Jolla, CA, USA.
Background: Neurocognitive health is influenced by multiple modifiable and non-modifiable lifestyle factors. Machine learning tools offer a promising approach to better understand complex models of cognitive function. We used extreme gradient boosting (XG Boost), an algorithm of decision-tree modeling, to analyze the association between 15 late-life lifestyle and demographic factors with episodic memory performance.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, India.
Background: In the early stages of typical Alzheimer's disease, there is a well-documented pattern of memory deficits, especially episodic memory, substantiated with evidence of medial temporal lobe atrophy, specifically of the hippocampus in line with the memory deficits. Studies have shown that several other demographic, biological, and lifestyle factors influence memory and there is a need for identifying early risk factors and for the development of clinical intervention programs to delay or prevent cognitive decline. Therefore, the objective of this study is to explore the impact of various factors on episodic memory decline in an urban cohort.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
University of California, Berkeley, Berkeley, CA, USA.
Background: Although it has been estimated that modifiable risk factors account for around 40% of population variability in dementia risk, understanding how risk factors are related to one another and to brain pathology and cognition has been challenging. We used a clustering approach to examine patterns of risk factor interrelationships and to investigate how these patterns affect relationships between pathology and cognition.
Method: We collected risk factor data concerning health, lifestyle, sleep, and personality from 149 cognitively normal older adults (73±6.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!