An analytical model considering modulation-dependent nonlinear effects and second-order interactions between signal and optical amplifier noise is presented for Nyquist-spaced wavelength-division-multiplexing optical communication systems. System performance of dual-polarization modulation formats, such as DP-QPSK, DP-16QAM, and DP-64QAM, is investigated using both the analytical model and numerical simulations. A good agreement between analytical and numerical results shows that, in the case of full-field nonlinearity compensation, accounting for second-order interactions becomes essential to predict system performance of both single- and multi-channel systems at optimum launched powers and beyond. This effect is validated via numerical simulations for signal bandwidths up to ∼1 THz.
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http://dx.doi.org/10.1364/OL.42.003351 | DOI Listing |
Fertil Steril
January 2025
Department of Health Behavior and Biological Sciences, School of Nursing, University of Michigan, Ann Arbor, Michigan.
Objective: To expand knowledge on physical outcomes and psychosocial experiences of oocyte donors after donation across 3 age cohorts.
Design: Cross-sectional mixed-methods survey.
Patients: A total of 363 participants (ages: 22-71 years, M = 38.
J Transl Med
January 2025
Department of Ophthalmology, Renmin Hospital of Wuhan University, Jiefang Road, Wuhan, Hubei, 430060, China.
Diabetic retinopathy is a major ocular complication of diabetes, characterized by progressive retinal microvascular damage and significant visual impairment in working-age adults. Traditional bulk RNA sequencing offers overall gene expression profiles but does not account for cellular heterogeneity. Single-cell RNA sequencing overcomes this limitation by providing transcriptomic data at the individual cell level and distinguishing novel cell subtypes, developmental trajectories, and intercellular communications.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou, 310058, China.
We conducted two experiments to examine the lexical and sub-lexical processing of Chinese two-character words in reading. We used a co-registration electroencephalogram (EEG) for the first fixation on target words. In Experiment 1, whole-word occurrence frequency and initial constituent character frequency were orthogonally manipulated, while in Experiment 2, whole-word occurrence frequency and end constituent character frequency were orthogonally manipulated.
View Article and Find Full Text PDFBiomaterials
January 2025
School of Life Science, Chongqing University, Chongqing, 400044, China. Electronic address:
In-situ tumor vaccination remains challenging due to difficulties in the exposure and presentation of tumor-associated neoantigens (TANs). In view of the central role of lipid metabolism in cell fate determination and tumor-immune cell communication, here we report a photo-controlled lipid metabolism nanoregulator (PLMN) to achieve robust in-situ adjuvant-free vaccination, which is constructed through hierarchically integrating photothermal-inducible arachidonate 15-lipoxygenase (ALOX15)-expressing plasmids, cypate and FIN56 into cationic liposomes. Near-infrared light (NIR) stimulation triggers on-demand ALOX15 editing and causes excessive accumulation of downstream pro-ferroptosis lipid metabolites.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
January 2025
Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Purpose: Previous studies have reported divergent sexual responses to aging; however, specific variations in gene expression between aging males and females and their potential association with age-related retinal diseases remain unclear. This study collected data from public databases and developed a comprehensive comparison of retina between aging females and males.
Methods: Single-cell RNA (scRNA) and bulk RNA sequencing data of the aging retina from females and males in public databases were utilized for integrated analysis to investigate sex-biased expression in retina.
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