Objective: To improve the pharmaceutical behavior of the oral antidiabetic agent gliclazide through the synthesis of multicomponent crystals with tromethamine.
Methods: Multicomponent crystals were prepared by solvent evaporation method, kneading, and combining mechanical and thermal activation. DSC, FT-IR spectroscopy, X-ray diffraction, SEM-EDS, and SSNMR were used to investigate their formation. Measurements of solubility and dissolution rate were carried out for the pharmaceutical characterization.
Results: The formation of multicomponent crystals of gliclazide and tromethamine was confirmed by all the techniques. In particular, FT-IR and NMR measurements revealed that the interaction between drug and coformer leads to significant changes of the hydrogen bond scheme, and that almost all the functional groups of the two molecules are involved. The dissolution profile of the new phase is significantly better than that of both pure gliclazide and of the reference commercial product Diabrezide.
Conclusions: The new system shows an improved pharmaceutical behavior and could be formulated in a dosage form to obtain a rapid and complete release of the drug available for absorption.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/03639045.2017.1386208 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Elaborate Designed Three-Dimensional Hierarchical Conductive MOF/LDH/CF Nanoarchitectures for Superior Capacitive Deionization.
Angew Chem Int Ed Engl
January 2025
Fujian University of Technology, College of Ecological Environment and Urban Construction, 69, Xuefu South Road, Fuzhou 350118, China, 350118, Fuzhou, CHINA.
Rational exploration of cost-effective, durable, and high-performance electrode materials is imperative for advancing the progress of capacitive deionization (CDI). The integration of multicomponent layered double hydroxides (LDHs) with conjugated conductive metal-organic frameworks (c-MOFs) to fabricate bifunctional heterostructure electrode materials is considered a promising strategy. Herein, the fabrication of hierarchical conductive MOF/LDH/CF nanoarchitectures (M-CAT/LDH/CF) as CDI anodes via a controllable grafted-growth strategy is reported.
View Article and Find Full Text PDFUltrasound-assisted and Efficient Multicomponent Synthesis of 4H-Pyran Derivatives catalyzed by LiOH.H2O in Water.
Curr Org Synth
January 2025
Laboratoire de Chimie Organique (LR17ES08), Faculté des Sciences de Sfax, University of Sfax, Route de Soukra Km 3.5, BP 1171, 3000, Sfax, Tunisia.
Aim And Objective: It is well established that 4H-pyran derivatives hold a significant position in synthetic organic chemistry due to their diverse biological and pharmacological properties. This work aims to introduce a novel synthetic pathway for highly functionalized 4H-pyran derivatives, achieved through a 1,4-Michael addition followed by a cascade cyclization. This reaction is catalyzed by LiOH·H2O under ultrasonic irradiation in water, offering an efficient and environmentally friendly approach.
View Article and Find Full Text PDFFerroelectric Nematic Liquid Crystals Showing High Birefringence.
Adv Sci (Weinh)
January 2025
South China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, South China University of Technology, Guangzhou, 510640, China.
High birefringence nematic liquid crystals are particularly demanded for adaptive optics applications in the infrared spectrum because it enable a thinner cell gap for achieving fast response time and improved diffraction efficiency. The emerging ferroelectric nematic liquid crystals have attracted widespread interest in soft matter due to their unique combination of ferroelectricity and fluidity. However, the birefringence, which is one of the most important optical parameters in electro-optic devices, is not large enough (<0.
View Article and Find Full Text PDFDrug Property Optimization: Design, Synthesis, and Characterization of Novel Pharmaceutical Salts and Cocrystal-Salt of Lumefantrine.
Mol Pharm
January 2025
Department of Industrial and Molecular Pharmaceutics, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States.
Lumefantrine (LMF) is a low-solubility antimalarial drug that cures acute, uncomplicated malaria. It exerts its pharmacological effects against erythrocytic stages of spp. and prevents malaria pathogens from producing nucleic acid and protein, thereby eliminating the parasites.
View Article and Find Full Text PDFEvaporation Kinetics and Final Particle Morphology of Multicomponent Salt Solution Droplets.
J Phys Chem A
January 2025
School of Chemistry, University of Bristol, Bristol BS8 1TS, U.K.
In both nature and industry, aerosol droplets contain complex mixtures of solutes, which in many cases include multiple inorganic components. Understanding the drying kinetics of these droplets and the impact on resultant particle morphology is essential for a variety of applications including improving inhalable drugs, mitigating disease transmission, and developing more accurate climate models. However, the previous literature has only focused on the relationship between drying kinetics and particle morphology for aerosol droplets containing a single nonvolatile component.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!