Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Boundaries mediate long-distance interactions between enhancers and promoters in the Drosophila Bithorax complex.
PLoS Genet
December 2018
Department of the Control of Genetic Processes, Institute of Gene Biology Russian Academy of Sciences, Moscow, Russia.
Drosophila bithorax complex (BX-C) is one of the best model systems for studying the role of boundaries (insulators) in gene regulation. Expression of three homeotic genes, Ubx, abd-A, and Abd-B, is orchestrated by nine parasegment-specific regulatory domains. These domains are flanked by boundary elements, which function to block crosstalk between adjacent domains, ensuring that they can act autonomously.
View Article and Find Full Text PDFThe role of Ultrabithorax in the patterning of adult thoracic muscles in Drosophila melanogaster.
Dev Genes Evol
February 2001
Department of Neurobiology and Behavior, Cornell University, W121 Seeley G. Mudd Hall, Ithaca, NY 14583-2702, USA.
Mutations in the homeotic gene, Ultrabithorax (Ubx), result in the transformation of the third thoracic (T3) segment into the second thoracic (T2) segment. Although it has been well established that these mutations have striking effects on adult epidermal structures in T3, the effect of these mutations on the adult musculature has been controversial. In this study, a series of Ubx regulatory mutations, anterobithorax, bithorax, postbithorax, and bithoraxoid, as well as combinations of these alleles were used to reevaluate the role of Ubx in the patterning of the T3 musculature.
View Article and Find Full Text PDFMuscles in the Drosophila second thoracic segment are patterned independently of autonomous homeotic gene function.
Curr Biol
April 1997
National Centre for Biological Sciences, Tata Institute of Fundamental Research, P.O. Box 1234, IISc Campus, Bangalore, 560012, India.
Background: In Drosophila, segment-specific muscle pattern is thought to be determined by the autonomous function of homeotic selector genes in the mesoderm in combination with inductive cues from the developing epidermis and nervous system. Here, we have examined the roles of homeotic genes in the patterning of the somatic muscles of the thoracic segments of Drosophila.
Results: We determined the expression patterns of homeoproteins in the mesoderm of the thoracic segments during embryonic and adult development.
Effect of polymorphism in the Drosophila regulatory gene Ultrabithorax on homeotic stability.
Science
January 1996
Department of Biology, University of Michigan, Ann Arbor 48109-1048, USA.
Development is buffered against unpredictable environmental and genetic effects. Here, a molecular genetic analysis of one type of developmental homeostasis, the establishment of thoracic segmental identity under the control of the Ultrabithorax (Ubx) gene in Drosophila melanogaster, is presented. Flies were artificially selected for differential sensitivity to the induction of bithorax phenocopies by ether vapor.
View Article and Find Full Text PDFSetting limits on homeotic gene function: restraint of Sex combs reduced activity by teashirt and other homeotic genes.
EMBO J
March 1994
Department of Developmental Biology, Stanford University School of Medicine, CA 94305-5427.
Each of the homeotic genes of the HOM or HOX complexes is expressed in a limited domain along the anterior-posterior axis. Each homeotic protein directs the formation of characteristic structures, such as wings or ribs. In flies, when a heat shock-inducible homeotic gene is used to produce a homeotic protein in all cells of the embryo, only some cells respond by altering their fates.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!