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Multiple Typing Approach to Characterize Strains from Captive and Livestock Species in Northern Italy Suggests the Circulation of Type-II Variants.
Animals (Basel)
December 2024
Department of Veterinary Medical Sciences (DIMEVET), Alma Mater Studiorum University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano Emilia, BO, Italy.
is a widespread foodborne parasite that affects both humans and animals worldwide. The genetic characterization of this parasite has become crucial due to its epidemiological and clinical implications. The present study focused on the direct genetic characterization of -positive DNA samples from Northern Italy, using three standardized genotyping methods.
View Article and Find Full Text PDFA population study of Toxoplasma gondii in the Amazon region expands current knowledge of the genetic diversity in South America.
PLoS Negl Trop Dis
December 2024
Department of Microbiology, University of Tennessee, Knoxville, Tennessee, United States of America.
Previous studies have reported high diversity between and within populations of Toxoplasma gondii in South America. In the present study, isolates of T. gondii from chickens were obtained from the Amazon region.
View Article and Find Full Text PDFGenotyping of human isolates from human toxoplasmosis outbreak: Restriction Fragment Length Polymorphism and Sanger Sequencing.
Braz J Microbiol
November 2024
Laboratório de Doenças Parasitárias (LADOPAR), Departamento de Medicina Veterinária Preventiva, Centro de Ciências (CCR), Universidade Federal de Santa Maria (UFSM), Av. Roraima, n°1000, Prédio 63D, Bairro Camobi, Santa Maria, RS, CEP 97105-900, Brasil.
Toxoplasmosis is a parasitic disease caused by infection with Toxoplasma gondii, capable of infecting a wide range of hosts. The parasite exhibits a broad genetic diversity, necessitating genotypic characterization for genotype identification and associations with epidemiological information. Therefore, the Restriction Fragment Length Polymorphism (RFLP) technique is used for characterization.
View Article and Find Full Text PDFTrend in serological and molecular diagnostic methods for Toxoplasma gondii infection.
Eur J Med Res
October 2024
Health Park Co., Ltd, Seoul, 02447, Republic of Korea.
Background: Toxoplasma gondii, an intracellular parasite, is a significant cause of zoonotic disease, with an estimated one-third of the world's human population believed to be infected. T. gondii is transmitted to humans through the consumption of contaminated water, soil, vegetables, fruits, shellfish or undercooked meat, and can also be passed from human to human through vertical transmission, transplants and blood transfusion.
View Article and Find Full Text PDFHypermigration of macrophages through the concerted action of GRA effectors on NF-κB/p38 signaling and host chromatin accessibility potentiates dissemination.
mBio
October 2024
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Unlabelled: Mononuclear phagocytes facilitate the dissemination of the obligate intracellular parasite . Here, we report how a set of secreted parasite effector proteins from dense granule organelles (GRA) orchestrates dendritic cell-like chemotactic and pro-inflammatory activation of parasitized macrophages. These effects enabled efficient dissemination of the type II lineage, a highly prevalent genotype in humans.
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