AI Article Synopsis
- This text describes a straightforward method for targeting unprotected secondary amines through a process that changes their structure via C-N bond formation.
- The approach involves using a potent electrophilic aminating agent, which is produced by removing protective groups from N-Boc hydroxylamines.
- This protocol can be applied in either dearomatization or aryl C-H amination, enhancing the versatility of amine access in organic synthesis.
Article Abstract
We outline a simple protocol that accesses directly unprotected secondary amines by intramolecular C-N bond forming dearomatization or aryl C-H amination. The method is dependent on the generation of a potent electrophilic aminating agent released by in situ deprotection of O-Ts activated N-Boc hydroxylamines.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639464 | PMC |
| http://dx.doi.org/10.1021/jacs.7b07830 | DOI Listing |
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