In this study, we developed a microdevice concept for drug/fluidic transport taking an inspiration from supramolecular motor found in biological cells. Specifically, idealized multi-functional design geometry (nozzle/diffuser/nozzle) was developed for (i) fluidic/particle transport; (ii) particle separation; and (iii) droplet generation. Several design simulations were conducted to demonstrate the working principles of the multi-functional device. The design simulations illustrate that the proposed design concept is feasible for multi-functionality. However, further experimentation and optimization studies are needed to fully evaluate the multifunctional device concept for multiple applications.
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http://dx.doi.org/10.3390/bioengineering4020037 | DOI Listing |
PLoS One
January 2025
FAMERP- Faculty of Medicine of São José do Rio Preto, São José do Rio Preto, Brazil.
Motivation is of great importance in the teaching-learning process, because motivated students seek out opportunities and show interest and enthusiasm in carrying out their tasks. The objective of this review is to identify and present the information available in the literature on the status quo of motivation among nursing program entrants. This is a qualitative scoping review study, a type of literature review designed to map out and find evidence to address a specific research objective, following the Joanna Briggs Institute methodology.
View Article and Find Full Text PDFBull Math Biol
January 2025
Université Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, 38000, Grenoble, France.
The extracellular matrix (ECM) is a complex structure involved in many biological processes with collagen being the most abundant protein. Density of collagen fibers in the matrix is a factor influencing cell motility and migration speed. In cancer, this affects the ability of cells to migrate and invade distant tissues which is relevant for designing new therapies.
View Article and Find Full Text PDFDrug Deliv Transl Res
January 2025
Leicester Institute of Pharmaceutical, Health and Social Care Innovations, Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK.
The use of dissolving microneedle arrays (dMNA) for intradermal and transdermal drug delivery has been a growing trend in the field for the past decades. However, a lack of specific regulatory standards still hinders their clinical development and translation to market. It is also well-known that dMNA composition significantly impacts their performance, with each new formulation potentially presenting a challenge for developers, manufacturers and regulatory agencies.
View Article and Find Full Text PDFJ Adv Nurs
January 2025
Department of Historical, Philosophical and Religious Studies, Umeå University, Umeå, Sweden.
Aim(s): To explore the understandings of spiritual care among nursing staff at an Swedish oncology clinic, with a special focus on changes over time.
Design: Qualitative, longitudinal, descriptive design.
Methods: A questionnaire-based replication study conducted in 2003 (N = 68) and 2023 (N = 47), comparative and thematic analysis.
J Adv Nurs
January 2025
School of Nursing, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Aim: To synthesise literature on the aging characteristics of people with long-term physical disabilities and inform future nursing research, education, practice and health policy.
Design: Scoping review.
Data Source: Literature searches were performed in the CINAHL, PubMed, and PsycINFO databases in April 2024.
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