Introduction: Symptomatic dermographism (SD) is the most common form of physical urticaria. However, the role of neuroimmune mechanisms in SD is unclear.
Aim: To investigate circulating levels of brain-derived neurotrophic factor (BDNF) in symptomatic dermographism.
Material And Methods: Thirty-two patients suffering from SD and 33 healthy subjects were included in the study. Serum BDNF levels were determined by a human enzyme-linked immunoassay (ELISA) kit. The serum C-reactive protein concentration and eosinophil counts in peripheral blood were evaluated.
Results: The BDNF serum levels were detectable in both SD patients and healthy controls. The BDNF serum levels were significantly higher in patients with SD compared with healthy controls ( = 0.004). There was a positive but weak correlation between serum BDNF and CRP levels; it was not statistically significant ( = 0.211, = 0.255). There was also a positive but weak correlation between serum BDNF and eosinophil counts; it was not statistically significant ( = 0.271, = 0.141).
Conclusions: The present study shows that BDNF is increased in the serum levels of patients with SD, suggesting a role for BDNF in the pathophysiology of this disorder.
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| http://dx.doi.org/10.5114/ada.2017.69315 | DOI Listing |
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