Pteridic acids C-G spirocyclic polyketides from the marine-derived Streptomyces sp. SCSGAA 0027.

J Antibiot (Tokyo)

Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.

Published: November 2017

Five new pteridic acids C-G (1-5) were isolated from a culture broth of the marine-derived actinomycete Streptomyces sp. SCSGAA 0027. Their complete structures were elucidated on the basis of NMR data, modified Mosher's method and quantum chemical calculations. Furthermore, their cytotoxicity, antiviral and antimicrobial activities were also evaluated.

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http://dx.doi.org/10.1038/ja.2017.105DOI Listing

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