AI Article Synopsis
- The study investigates the levels of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) in early-stage diabetic retinopathy (DR) using diabetic Macaca mulattas (monkeys) as subjects.
- Three diabetic monkeys were compared with three healthy controls to assess changes in VEGF and PEDF expression in the retinas.
- Results showed increased VEGF and decreased PEDF levels in the diabetic group, indicating their potential roles in the development and diagnosis of diabetic retinopathy.*
Article Abstract
Objective: To explore the expression of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) in early stage of diabetic retinopathy (DR) in Macaca mulatta.
Methods: Three diabetic Macaca mulattas induced by high-fat diet were identified for early stage of diabetic retinopathy according to the fasting plasma glucose, hemoglobin Alc (HbA1c), fundus photograph and duration of diabetes, with another 3 age-matched healthy Macaca mulattas as control. The expression of VEGF and PEDF in the retinas of Macaca mulatta were detected by quantitative real-time PCR and immunohistochemistry.
Result: In early stage of diabetic retinopathy, VEGF mRNA and protein of the diabetic group were both significantly increased compared with the control group (P<0.05). PEDF expression at both mRNA and protein levels was significantly decreased in diabetic Macaca mulattas compared with the control group (P<0.01 and 0.05 respectively).
Conclusion: Retinal VEGF expression is increased and PEDF expression is decreased in early stage of diabetic retinopathy, suggesting their involvement in the occurrence of diabetic retinopathy and their value in assisting in the early diagnosis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765491 | PMC |
| http://dx.doi.org/10.3969/j.issn.1673-4254.2017.09.13 | DOI Listing |
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