We discuss the existing data on anal precancers and demonstrate the impact of evidence gaps and uncertainty on a clinical decision model developed to provide clinical guidance for management of anal precancers.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771459 | PMC |
http://dx.doi.org/10.1002/cncr.31033 | DOI Listing |
Virology
January 2025
Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Department of Surgery, William S. Middleton Memorial Veteran's Hospital, Madison, WI, USA.
Despite the availability of several human papillomavirus (HPV) vaccines, the incidence of HPV-associated anal cancer is growing at a rate of 2.2% each year. As shown in results from the recent Phase III ANCHOR study, the treatment of high-grade anal lesions in people living with HIV (PLWH) can significantly reduce rates of anal cancer development compared to active surveillance alone.
View Article and Find Full Text PDFArch Gynecol Obstet
November 2024
EU Real World Evidence, Xcenda GmbH, Lange Laube 31, 30159, Hanover, Germany.
Biomedicines
August 2024
Laboratory of Virology, National Institute for Infectious Diseases "Lazzaro Spallanzani" (IRCCS), 00149 Rome, Italy.
Background: Human papillomavirus (HPV) infection is linked to several cancers, including anal and oral cancers. The incidence of anal cancer is particularly high among HIV-positive men who have sex with men (MSM). DNA methylation markers have shown promise as biomarkers for identifying precancerous lesions and cancer in HPV-infected individuals.
View Article and Find Full Text PDFOral Dis
August 2024
Oral Diagnosis Department, Piracicaba Dental School, State University of Campinas, Piracicaba, Brazil.
Background: Non-AIDS defining malignancies present a growing challenge for persons with HIV (PWH), yet tailored interventions for timely cancer diagnosis are lacking. The Spanish IMPAC-Neo protocol was designed to compare two comprehensive cancer screening strategies integrated into routine HIV care. This study reports baseline data on the prevalence and types of precancerous lesions and early-stage cancer among participants at enrolment.
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