In the present study, biological activity and chemical composition of two crude extracts of endophytic fungal strains of genera isolated from two species of aquatic macrophytes: (Kunth) and (Mart.) were investigated. The nuclear magnetic resonance and mass spectrometry data provided the identification of three main compounds: curvulin (), spirostaphylotrichin R () and U (). The fragmentation mechanism of the precursor ions towards collision induced dissociation (CID) tandem mass spectrometry experiment (MS/MS) is also proposed. Furthermore, biological screening of the crude extracts displayed antileishmanial activity with IC values ranging from 70-84.2 μg.mL.
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| http://dx.doi.org/10.1080/14786419.2017.1380011 | DOI Listing |
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