AI Article Synopsis
- A systematic review and meta-analysis were conducted to assess the link between restless legs syndrome (RLS) and risks of cerebrovascular and cardiovascular issues.
- The study analyzed data from 8 eligible studies involving over 644,000 patients, revealing that RLS patients showed higher rates of hypertension, diabetes, and hyperlipidemia compared to controls.
- While RLS patients demonstrated increased all-cause mortality risk, the evidence did not support a higher risk for cerebrovascular and cardiovascular events, suggesting other confounding factors may be at play.
Article Abstract
Objective: We performed a systematic review and meta-analysis to evaluate the proposed association of restless legs syndrome (RLS) with cerebrovascular/cardiovascular outcomes.
Methods: We calculated the corresponding odds ratios on the prevalence of cerebrovascular/cardiovascular risk factors and standardized mean differences on the reported mean age at baseline between RLS patients and controls. We also calculated the corresponding risk ratios and adjusted for potential confounders hazard ratios (HRs ) on the reported outcomes of interest between RLS patients and controls.
Results: We identified 8 eligible studies (644 506 patients, mean age: 60.2 years, 36.2% males; 3.3% with RLS). RLS patients were found to have significantly higher prevalence of hypertension (P = .002), diabetes (P = .003) and hyperlipidemia (P = .010) compared to controls. In the unadjusted analyses of prospective observational studies, RLS patients were found to have significantly higher risk for cerebrovascular ischaemia (P = .01) and all-cause mortality (P = .04) compared to controls during follow-up, while in the adjusted for potential confounders analyses RLS patients were only found to have a higher risk of all-cause mortality (HR adjusted=1.52, 95% CI: 1.17-1.97, P = .002).
Conclusions: The present report does not provide evidence for an increased risk of cerebrovascular and cardiovascular events in RLS patients, which highlights the vast presence of confounding factors.
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| http://dx.doi.org/10.1111/ane.12848 | DOI Listing |
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