AI Article Synopsis
- Genetic polymorphisms, specifically the Val158Met variant of the Catechol-O-Methyltransferase gene, significantly affect white matter structure and brain function development in healthy adults.
- Using diffusion-weighted imaging and Tract-Based Spatial Statistics, the study analyzed white matter integrity in a sample of 82 healthy individuals.
- Findings revealed that the interaction between genotype and sex influences the morphology of the corpus callosum, with male homozygotes showing higher fractional anisotropy compared to female carriers.
Article Abstract
Background: Genetic polymorphisms play a significant role in determining brain morphology, including white matter structure and may thus influence the development of brain functions. The main objective of this study was to examine the effect of Val158Met (rs4680) polymorphism of Catechol--Methyltransferase () gene on white matter connectivity in healthy adults.
Methods: We used a whole-brain diffusion-weighted imaging method with Tract-Based Spatial Statistics (TBSS) analysis to examine white matter structural integrity in intrinsic brain networks on a sample of healthy subjects ( = 82).
Results: Results revealed a sex-specific effect of on corpus callosum (CC): in males only, homozygotes had significantly higher fractional anisotropy (FA) compared to -carriers. Volume-of-interest analysis showed a genotype by sex interaction on FA in genu and rostral midbody of CC, whereby Val males demonstrated higher FA than Met females.
Conclusions: These results demonstrate the key effect of genes by sex interaction, rather than their individual contribution, on the corpus callosum anatomy.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607550 | PMC |
| http://dx.doi.org/10.1002/brb3.786 | DOI Listing |
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