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Iterative analysis of cerebrovascular reactivity dynamic response by temporal decomposition. | LitMetric

AI Article Synopsis

  • The study aims to enhance measurements of cerebrovascular reactivity (CVR) and carbon dioxide (CO) arrival times using an iterative analysis method that breaks down the CO-BOLD relationship into different temporal elements.
  • Researchers redefined how they measure CO arrival times and separated responses to increases and decreases in CO levels, using data from 25 normal subjects to create reference atlases for analysis.
  • The findings suggest that the new CO arrival time definition improves the data fit and that excluding dynamic phases leads to a stable but limited understanding of CVR, highlighting the importance of detailed temporal analysis.

Article Abstract

Objective: To improve quantitative cerebrovascular reactivity (CVR) measurements and CO arrival times, we present an iterative analysis capable of decomposing different temporal components of the dynamic carbon dioxide- Blood Oxygen-Level Dependent (CO -BOLD) relationship.

Experimental Design: Decomposition of the dynamic parameters included a redefinition of the voxel-wise CO arrival time, and a separation from the vascular response to a stepwise increase in CO (Delay to signal Plateau - DTP) and a decrease in CO (Delay to signal Baseline -DTB). Twenty-five (normal) datasets, obtained from BOLD MRI combined with a standardized pseudo-square wave CO change, were co-registered to generate reference atlases for the aforementioned dynamic processes to score the voxel-by-voxel deviation probability from normal range. This analysis is further illustrated in two subjects with unilateral carotid artery occlusion using these reference atlases.

Principal Observations: We have found that our redefined CO arrival time resulted in the best data fit. Additionally, excluding both dynamic BOLD phases (DTP and DTB) resulted in a static CVR, that is maximal response, defined as CVR calculated only over a normocapnic and hypercapnic calibrated plateau.

Conclusion: Decomposition and novel iterative modeling of different temporal components of the dynamic CO -BOLD relationship improves quantitative CVR measurements.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607533PMC
http://dx.doi.org/10.1002/brb3.705DOI Listing

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