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Local Control of Conjunctival Malignant Melanoma by Proton Beam Therapy in a Patient With No Metastasis in Six Years From to Nodular Lesions.
J Med Cases
January 2025
Department of Dermatology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama City 700-8558, Japan.
Conjunctival malignant melanoma is extremely rare, with no standard of care established at moment. Here we report a 65-year-old woman, as a hepatitis B virus (HBV) carrier, who presented concurrently a liver mass and lower bulbar conjunctival pigmented lesions in the right eye. Needle liver biopsy and excisional conjunctival biopsy showed hepatocellular carcinoma and conjunctival malignant melanoma , respectively.
View Article and Find Full Text PDFOrbital apex syndrome secondary to Sweet syndrome.
BMJ Case Rep
January 2025
Department of Ophthalmology, Rochdale Infirmary, Rochdale, UK.
Sweet syndrome (SS), or acute febrile neutrophilic dermatosis, is a dermatologic, auto-inflammatory disorder of unclear origin, often accompanied by systemic inflammation affecting various tissues, including the eyes. Common ocular manifestations include conjunctivitis but can extend to other ocular tissues. Orbital apex syndrome (OAS) involves damage to several cranial nerves transversing the orbital apex, leading to ophthalmoplegia and vision loss.
View Article and Find Full Text PDFAssociation of obesity with orbital fat expansion in thyroid eye disease.
BMC Ophthalmol
January 2025
Department of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, No. 138, Sheng Li Road, Tainan, 704, Taiwan.
Background: To investigate the association between obesity and orbital fat expansion in proptosis of thyroid eye disease.
Methods: This observational study retrospectively enrolled 87 participants who received orbital fat decompression surgery for thyroid eye disease. Primary outcome measures included average body mass index (BMI) and the proportion of the study sample with overweight and obesity, compared with the general Taiwanese population.
Genome mining of nonenzymatic ortho-quinone methide-based pseudonatural products from ascidian-derived fungus Diaporthe sp.SYSU-MS4722.
Bioorg Chem
January 2025
School of Marine Sciences, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, Pearl River Estuary Marine Ecosystem Research Station, Ministry of Education, Southern Laboratory of Ocean Science and Engineering (Guangdong, Zhuhai), Zhuhai 519000, China. Electronic address:
Article Synopsis
- Ortho-quinone methides (o-QMs) are reactive intermediates formed from clavatol that lead to pseudonatural products (PNPs) in fungi, which can have significant biological activities.
- Genome mining identified a clavatol biosynthetic gene cluster (BGC) in the Diaporthe sp. SYSU-MS4722 fungus, allowing for the heterologous expression of key genes in Aspergillus oryzae NSAR1, leading to the discovery of 13 new clavatol-based PNPs.
- Structural analysis using various spectroscopic techniques confirmed the identities of these compounds, revealing several with notable anti-fibrotic activity.
Primary Systemic Amyloidosis Characterized by Multiple Keratinous Cysts: A Case Report.
J Cutan Pathol
December 2024
Department of Dermatology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Article Synopsis
- A 67-year-old male presented with skin plaques and bruising on the neck and hands for 2 years, along with nail issues.
- Histopathological tests indicated the presence of keratinous cysts and eosinophilic material, which tested positive for Congo red staining.
- A bone marrow biopsy confirmed multiple myeloma, leading to a diagnosis of primary systemic amyloidosis alongside multiple myeloma.
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