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File: /var/www/html/application/controllers/Detail.php
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Discovery and structure-based design of 4,6-diaminonicotinamides as potent and selective IRAK4 inhibitors. | LitMetric
The identification of small molecule inhibitors of IRAK4 for the treatment of autoimmune diseases has been an area of intense research. We discovered novel 4,6-diaminonicotinamides which potently inhibit IRAK4. Optimization efforts were aided by X-ray crystal structures of inhibitors bound to IRAK4. Structure activity relationship (SAR) studies led to the identification of compound 29 which exhibited sub-micromolar potency in a LTA stimulated cellular assay.
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