Background: Skin impedance is a biological signal that has been employed in the measurement of pain. However, there are few scientific data on skin impedance, with a great variety of assessment methods and controversial results.
Objective: To examine the intra- and inter-rater reliability of skin impedance measurement in individuals with chronic neck pain.
Methods: This is a blind cross-sectional study. Thirty individuals of both genders, aged between 18 and 45 years and with chronic neck pain were included in the study. Two examiners assessed skin impedance of the upper and lower limbs and torso at two intervals separated by one week. For statistical analysis, we used the intraclass correlation coefficient (ICC2,3) to determine the intra- and inter-rater reliability of skin impedance, with its respective confidence interval of 95%, standard error of measurement (SEM) and minimum detectable change (MDC).
Results: The intra-rater reliability was considered substantial to excellent, with ICC values ranging between 0.843 and 0.978, SEM between 0.58 and 15.26 Ω, and MDC between 1.61 and 42.31 Ω. The inter-rater reliability was moderate to excellent, with ICC values ranging between 0.761 and 0.997, SEM ranging between 0.22 and 16.72 Ω, and MDC ranging between 0.63 and 46.35 Ω.
Conclusion: The measurement of skin impedance of the upper and lower limbs and torso in individuals with chronic neck pain has acceptable reliability values when considered at different times and by different examiners.
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http://dx.doi.org/10.3233/BMR-169753 | DOI Listing |
Iran J Basic Med Sci
January 2025
Tissue Engineering and stem cells research center, Shahroud University of Medical Sciences, Shahroud, Iran.
Objectives: For designing a suitable hydrogel, two crosslinked Alginate/ Carboxymethyl cellulose (Alg/CMC) hydrogel, using calcium chloride (Ca) and glutaraldehyde (GA) as crosslinking agents were synthesized and compared.
Materials And Methods: All samples were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), Blood compatibility (BC), Blood clotting index (BCI), weight loss (WL), water absorption (WA), pH, and Electrochemical Impedance Spectroscopy (EIS). Cell viability and cell migration were investigated using the MTT assay and the wound scratch test, respectively.
Anal Methods
January 2025
ampere - Laboratório de Plataformas Eletroquímicas - Universidade Federal de Santa Catarina, Departamento de Química, 88040-900 Florianópolis, SC, Brazil.
Terbinafine hydrochloride (TBF) is a broad-spectrum antifungal used to treat various dermatophyte infections affecting the skin, hair, and nails. Accurate, sensitive, and affordable analytical methods are crucial for quantifying this drug. In this study, we report on the use of carbon-based electrodes for the electrochemical determination of TBF in pharmaceutical samples, including raw materials and tablets.
View Article and Find Full Text PDFBiosens Bioelectron
January 2025
College of Mathematical Medicine, Zhejiang Normal University, Jinhua, China; Affiliated Dongyang Hospital of Wenzhou Medical University, Jinhua, China. Electronic address:
Pathological conditions in organisms often arise from various cellular or tissue abnormalities, including dysregulation of cell numbers, infections, aberrant differentiation, and tissue pathologies such as lung tumors and skin tumors. Thus, developing methods for analyzing and identifying these biological abnormalities presents a significant challenge. While traditional bioanalytical methods such as flow cytometry and magnetic resonance imaging are well-established, they suffer from inefficiencies, high costs, complexity, and potential hazards.
View Article and Find Full Text PDFMicrosyst Nanoeng
January 2025
Shien-Ming Wu School of Intelligent Engineering, South China University of Technology, Guangzhou, 511442, P. R. China.
Surface electromyogram (sEMG) serves as a means to discern human movement intentions, achieved by applying epidermal electrodes to specific body regions. However, it is difficult to obtain high-fidelity sEMG recordings in areas with intricate curved surfaces, such as the body, because regular sEMG electrodes have stiff structures. In this study, we developed myoelectrically sensitive hydrogels via 3D printing and integrated them into a stretchable, flexible, and high-density sEMG electrodes array.
View Article and Find Full Text PDFArch Dermatol Res
January 2025
Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
We have recently shown that fluoxetine (FX) suppressed polyinosinic-polycytidylic acid-induced inflammatory response and endothelin release in human epidermal keratinocytes, via the indirect inhibition of the phosphoinositide 3-kinase (PI3K)-pathway. Because PI3K-signaling is a positive regulator of the proliferation, in the current, highly focused follow-up study, we assessed the effects of FX (14 µM) on the proliferation and differentiation of human epidermal keratinocytes. We found that FX exerted anti-proliferative actions in 2D cultures (HaCaT and primary human epidermal keratinocytes [NHEKs]; 48- and 72-h; CyQUANT-assay) as well as in 3D reconstructed epidermal equivalents (48-h; Ki-67 immunohistochemistry).
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