Tissue distribution, bioaccumulation characteristics and health risk of antibiotics in cultured fish from a typical aquaculture area.

Unlabelled: The negative impacts of residual antibiotics in the environment on ecosystem and human health are big concerns. However, little information is available on the antibiotic bioaccumulation in aquaculture farms. In this study, the bioaccumulative potentials of 21 antibiotics in the plasma, bile, liver and muscle of cultured fish from a typical aquaculture area were systematically investigated.

Results: indicated that antibiotic distribution in the cultured fish was mainly influenced by species and specific substances. The mean values of log bioaccumulation factors (Log BAFs) for the detected antibiotics were in the range of 0.43-3.70, 0.36-4.75, -0.31-4.48, and 0.23-4.33 in the fish plasma, bile, liver and muscle tissues, respectively. For grass carp, both ciprofloxacin and enrofloxacin showed high transportability from the plasma to the muscle and liver. The correlations of various antibiotic concentrations between the plasma and the other three tissues indicated that the concentrations of ciprofloxacin and enrofloxacin in the fish tissues could be predicted by their concentrations in the plasma. Based on the calculated hazard quotients, human health risk evaluation of antibiotic exposure by fish consumption indicated that the consumption of these cultured fish posed low risks to human health.