Background: This study aimed to evaluate the effect of resistance training on the functional capacity of people with multiple sclerosis. Two groups were defined intentionally and divided based on the Expanded Disability Status Scale (EDSS): an experimental group (EG) consisting of 11 individuals, 18.2% with an EDSS Score of 0-3.0, 72.8% with a score of 3.5-5.5 and 9.1% with a score of 6.0-7.5; and a control group (CG) consisting of 12 subjects, 25.0% with a score of 0-3.0, 58.3% with a score of 3.5-5.5 and 16.7% with a score of 6.0-7.5.
Methods: The EG underwent 12 weeks of resistance training, while the CG did not. The Timed "Up & Go" test was used to measure the function of the lower limbs. The Timed 7.62 Meters Walk test and the Sit-to-stand test were used to assess the strength of the lower limbs. Balance, and the risk of falling, were assessed through the Berg Balance Test.
Results: At the beginning of the study, there were no differences between EG and CG in lower limb function. However, after the 12 weeks of resistance training, significant differences were found between the EG and the CG in the Timed "Up and Go" test (P=0.021), Timed 7.62 Meters Walk (P=0.027), Sit-to-stand (P=0.017) and Balance test (P=0.039).
Conclusions: This study's results indicate that this type of training can improve muscle strength and functional capacity in patients with multiple sclerosis.
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http://dx.doi.org/10.23736/S0022-4707.17.07621-6 | DOI Listing |
Sci Rep
January 2025
Department of Anesthesiology and Surgical Intensive Care Unit, Kunming Children's Hospital, Kunming, Yunnan, China.
Metabolic syndrome (Mets) in adolescents is a growing public health issue linked to obesity, hypertension, and insulin resistance, increasing risks of cardiovascular disease and mental health problems. Early detection and intervention are crucial but often hindered by complex diagnostic requirements. This study aims to develop a predictive model using NHANES data, excluding biochemical indicators, to provide a simple, cost-effective tool for large-scale, non-medical screening and early prevention of adolescent MetS.
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Eötvös Loránd University, Department of Physics of Complex Systems, Budapest, Hungary.
Patients with High-Grade Serous Ovarian Cancer (HGSOC) exhibit varied responses to treatment, with 20-30% showing de novo resistance to platinum-based chemotherapy. While hematoxylin-eosin (H&E)-stained pathological slides are used for routine diagnosis of cancer type, they may also contain diagnostically useful information about treatment response. Our study demonstrates that combining H&E-stained whole slide images (WSIs) with proteomic signatures using a multimodal deep learning framework significantly improves the prediction of platinum response in both discovery and validation cohorts.
View Article and Find Full Text PDFPaediatr Respir Rev
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Department of Respiratory Medicine, The Children's Hospital at Westmead, Westmead, Sydney, New South Wales 2145, Australia; Discipline of Paediatrics and Child Health, Faculty of Medicine, University of Sydney, Camperdown, Sydney, New South Wales 2006, Australia.
Physical activity is crucial for children's physical, cognitive, and social development, reducing the risk of non-communicable diseases and improving overall well-being. A major legacy of extremely preterm delivery is respiratory limitation with reduced lung function and decreased exercise capacity which can be further exacerbated by inactivity and deconditioning. Strategies to increase incidental physical activities in early childhood and participation in sport and more formal exercise programmes in middle childhood have the potential to optimize cardiopulmonary function, improve quality of life, and foster social interactions in childhood and beyond, thereby providing benefits that extend far beyond the physical domain.
View Article and Find Full Text PDFJ Prev Alzheimers Dis
February 2025
Department of Neurology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Indonesia/Dr Sardjto General Hospital Yogyakarta, Indonesia.
Dementia, is a critical global public health challenge with no effective pharmacological treatments. Recent research highlights the significant role of lifestyle interventions, particularly physical activity and dietary habits, in mitigating cognitive decline among the elderly and preventing the progression to dementia in individuals with Mild Cognitive Impairment (MCI). This comprehensive review explores the impact of physical exercise and dietary approaches on cognitive health, comparing strategies adopted in Western and Asian countries.
View Article and Find Full Text PDFCancer Lett
January 2025
Department of Medical Thoracic Oncology, Zhejiang Cancer Hospital, Institute of Basic Medicine and Cancer(IBMC),Chinese Academy of Sciences, Hangzhou, Zhejiang, China. Electronic address:
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