Aim: To quantify the association between diabetes and glaucoma using Meta-analysis.
Methods: PubMed and Embase were searched using medical subject headings and key words related to diabetes and glaucoma. The inclusion criteria were: 1) the study design was a prospective cohort study; 2) the exposure of interest was diabetes; 3) the outcome of interest was primary open angle glaucoma (POAG); 4) risk ratios (RR) and the corresponding 95% confidence interval (CI). Data were pooled using fixed effects models to take into account heterogeneity between studies. Seven prospective studies were selected. Diabetes increased the incidence of glaucoma by 36% (OR=1.36, 95% CI=1.25-1.50). There was no evidence of statistical heterogeneity (=0, =0.53) or publication bias (the funnel plot did not identify obvious asymmetry).
Results: Seven prospective cohort studies were incorporated in this Meta-analysis. The pooled RR of the association between POAG and diabetes based on the risk estimates of the seven cohort studies was 1.36 (95%CI=1.24-1.50), with no significant heterogeneity across studies (=0; =0.526). The sensitivity analysis yielded a range of RRs from 1.34 (95%CI=1.22-1.48) to1.40 (95%CI=1.18-1.67).
Conclusion: Diabetes is associated with a significantly increased risk of glaucoma.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596230 | PMC |
| http://dx.doi.org/10.18240/ijo.2017.09.16 | DOI Listing |
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