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Protocol for differentiating hematopoietic progenitor cells from human pluripotent stem cells in chemically defined monolayer culture.
STAR Protoc
January 2025
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China. Electronic address:
Human pluripotent stem cells (hPSCs) provide a powerful platform for generating hematopoietic progenitor cells (HPCs) and investigating hematopoietic development. Here, we present a protocol for maintaining hPSCs and inducing their differentiation into HPCs through the endothelial-to-hematopoietic transition (EHT) on vitronectin-coated plates. We outline steps for evaluating the efficiency of HPC generation and assessing their potential to differentiate into various hematopoietic lineages.
View Article and Find Full Text PDFDepletion of alloreactive B cells by drug- resistant chimeric alloantigen receptor T cells to prevent transplant rejection.
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January 2025
Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School; 30625 Hannover, NI, Germany. Electronic address:
Antibody-mediated rejection (AMR) remains a major complication after solid organ transplantation (SOT). Current treatment options are inefficient and result in drastic impairment of the general immunity. To selectively eliminate responsible alloreactive B cells characterized by anti-donor-HLA B-cell receptors (BCRs), we generated T cells overcoming rejection by antibodies (CORA-Ts) engineered with a novel chimeric receptor comprising a truncated donor-HLA molecule as antigen recognition domain.
View Article and Find Full Text PDFThe microbiota of cork and yellow stain as a model for a new route for the synthesis of chlorophenols and chloroanisoles from the microbial degradation of suberin and/or lignin.
Microbiome
January 2025
Instituto de Investigación de La Viña y El Vino, Escuela de Ingeniería Agraria, Universidad de León, Avenida de Portugal, 41, León, 24009, Spain.
Article Synopsis
- Cork is primarily used for wine bottle stoppers, but it can contain 2,4,6-trichloroanisole, which causes a musty odor that negatively affects wine quality and leads to financial losses.
- The presence of yellow stain in cork indicates a degradation linked to higher microbial populations, particularly filamentous fungi that break down lignin, and this microbiota contributes to the formation of chlorophenols and chloroanisoles.
- Research identified specific fungal and bacterial species associated with yellow stain and demonstrated that certain strains can convert p-hydroxybenzoate into phenol, which can then be chlorinated, potentially leading to the development of 2,4,6-trichlorophenol.
Energy optimization and plant comfort management in smart greenhouses using the artificial bee colony algorithm.
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Department of Robotics, Hanyang University, Ansan, 15588, Republic of Korea.
Agriculture is an essential component of human sustenance in this world. These days, with a growing population, we must significantly increase agricultural productivity to meet demand. Agriculture moved toward technologies as a result of the demand for higher yields with less resources.
View Article and Find Full Text PDFResearch on vehicle scheduling for forest fires in the northern Greater Khingan Mountains.
Sci Rep
January 2025
College of Energy and Transportation Engineering, Inner Mongolia Agricultural University, Hohhot, 010010, China.
In the face of forest fire emergencies, fast and efficient dispatching of rescue vehicles is an important means of mitigating the damage caused by forest fires, and is an effective method of avoiding secondary damage caused by forest fires, minimizing the damage caused by forest fires to the ecosystem, and mitigating the losses caused by economic development. this paper takes the actual problem as the starting point, constructs a reasonable mathematical model of the problem, for the special characteristics of the emergency rescue vehicle scheduling problem of forest fires, taking into account the actual road conditions in the northern pristine forest area, through the analysis of the cost of paths between the forest area and the highway, to obtain the least obstructed rescue paths, to narrow the gap between the theoretical model and the problem of the actual. Improvement of ordinary genetic algorithm, design of double population strategy selection operation, the introduction of chaotic search initialization population, to improve the algorithm's solution efficiency and accuracy, through the northern pristine forest area of Daxing'anling real forest fire cases and generation of large-scale random fire point simulation experimental test to verify the effectiveness of the algorithm, to ensure that the effectiveness and reasonableness of the solution to the problem of forest fire emergency rescue vehicle scheduling program.
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