Under most conditions, loop diuretics are K-wasting, requiring potassium supplementation. In this issue, Wang and colleagues demonstrate that in mice fed a low-Na, high-K diet, loop diuretics, in contrast, are K-sparing. This observation suggests that possible elevations in plasma K should be monitored when using a loop diuretic with a low-Na, high-K diet, particularly when in combination with a potassium supplement.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889197 | PMC |
| http://dx.doi.org/10.1016/j.kint.2017.05.022 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Characterization, ultrafiltration, depolymerization and gel formulation of ulvans extracted via a novel ultrasound-enzyme assisted method.
Ultrason Sonochem
December 2024
CINBIO, Universidade de Vigo, Departament of Chemical Engineering, Faculty of Sciences, Campus Ourense, Edificio Politécnico, As Lagoas 32004 Ourense, Spain.
Sea lettuce, or Ulva spp., dominates global algal biomass and significantly contributes to "green tides.", representing a sustainable source for biomaterials.
View Article and Find Full Text PDFReverse Solute Diffusion Enhances Sludge Dewatering in Dead-End Forward Osmosis.
Membranes (Basel)
September 2024
Yau Mathematical Sciences Center, Tsinghua University, Beijing 100084, China.
Wastewater treatment plants produce high quantities of excess sludge. However, traditional sludge dewatering technology has high energy consumption and occupies a large area. Dead-end forward osmosis (DEFO) is an efficient and energy-saving deep dewatering technology for sludge.
View Article and Find Full Text PDFA highly-selective biomimetic potassium channel.
Natl Sci Rev
August 2024
Key Laboratory for Intelligent Nano Materials and Devices of the Ministry of Education, State Key Laboratory of Mechanics and Control for Aerospace Structures, Institute for Frontier Science, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China.
Reproducing the outstanding selectivity achieved by biological ion channels in artificial channel systems can revolutionize applications ranging from membrane filtration to single-molecule sensing technologies, but achieving this goal remains a challenge. Herein, inspired by the selectivity filter structure of the KcsA potassium channel, we propose a design of biomimetic potassium nanochannels by functionalizing the wall of carbon nanotubes with an array of arranged carbonyl oxygen atoms. Our extensive molecular dynamics simulations show that the biomimetic nanochannel exhibits a high K permeation rate along with a high K/Na selectivity ratio.
View Article and Find Full Text PDFInfluence of proteolytic cleavage of ENaC's γ subunit upon Na and K handling.
Am J Physiol Renal Physiol
June 2024
Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
The epithelial Na channel (ENaC) γ subunit is essential for homeostasis of Na, K, and body fluid. Dual γ subunit cleavage before and after a short inhibitory tract allows dissociation of this tract, increasing channel open probability (P), in vitro. Cleavage proximal to the tract occurs at a furin recognition sequence (RKRR, in the mouse γ subunit).
View Article and Find Full Text PDFThe ENaC gamma subunit is essential for homeostasis of Na , K , and body fluid. Dual subunit cleavage before and after a short inhibitory tract allows dissociation of this tract, increasing channel open probability (P ), . Cleavage proximal to the tract occurs at a furin recognition sequence ( RKRR in mouse).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!