Int J Health Sci (Qassim)
Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.
Published: January 2017
Objectives: The primary objective of this study was to examine the appropriateness of candidemia management at a Veterans Affairs Medical Center as recommended by the 2009 Infectious Diseases Society of America (IDSA) guidelines for treatment of infections.
Methods: A retrospective analysis of 94 adult patients with blood cultures positive for spp. was performed. Patients were stratified by severity of disease into two groups: non-neutropenic, mild-moderate disease (Group 1, = 54, 56%) and non-neutropenic, moderate-severe disease (Group 2, = 40, 42%).
Results: Adherence to the IDSA recommendations for recommended antifungal drug, dose, and duration of therapy was low in both groups (16.7% in Group 1 and 17.5% in Group 2). Although adherence was not associated with higher clinical resolution of infection ( = 0.111), it was associated with a significantly lower mortality rate ( = 0.001) when compared to variance from the guidelines at 6 weeks.
Conclusion: Although adherence to published guidelines for treating patients with candidemia was suboptimal at our institution, patients that were managed based on the guidelines had a statistically lower mortality rate.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604274 | PMC |
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