Devices called functional appliances are commonly used in orthodontics for treating maxillary protrusion. These devices mechanically force the mandible forward to apply traction force to the mandibular condyle. This promotes cartilaginous growth in the small mandible. However, no studies have clarified how much traction force is applied to the mandibular condyle. Moreover, it remains unknown as to how anatomical characteristics affect this traction force. Therefore, in this study, we developed a device for measuring the amount of force generated while individual patients wore functional appliances, and we investigated the relationship between forces with structures surrounding the mandibular condyle. We compared traction force values with cone-beam computed tomography image data in eight subjects. The functional appliance resulted in a traction force of 339-1477gf/mm, with a mean value of 196.5gf/mm for the elastic modulus of the mandible. A comparison with cone-beam computed tomography image data suggested that the mandibular traction force was affected by the mandibular condyle and shape of the articular eminence. This method can contribute to discovering efficient treatment techniques more suited to individual patients.
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http://dx.doi.org/10.1016/j.jbiomech.2017.08.022 | DOI Listing |
ACS Appl Mater Interfaces
January 2025
Interdisciplinary Nanoscience Center, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C, Denmark.
High-throughput measurement of cellular traction forces at the nanoscale remains a significant challenge in mechanobiology, limiting our understanding of how cells interact with their microenvironment. Here, we present a novel technique for fabricating protein nanopatterns in standard multiwell microplate formats (96/384-wells), enabling the high-throughput quantification of cellular forces using DNA tension gauge tethers (TGTs) amplified by CRISPR-Cas12a. Our method employs sparse colloidal lithography to create nanopatterned surfaces with feature sizes ranging from sub 100 to 800 nm on transparent, planar, and fully PEGylated substrates.
View Article and Find Full Text PDFIn confluent cell monolayers, patterns of cell forces and motion are systematically altered near topological defects in cell shape. In turn, defects have been proposed to alter cell density, extrusion, and invasion, but it remains unclear how the defects form and how they affect cell forces and motion. Here, we studied +1/2 defects, and, in contrast to prior studies, we observed both tail-to-head and head-to-tail defect motion occurring at the same time in the same cell monolayer.
View Article and Find Full Text PDFSci Rep
January 2025
China Academy of Railway Sciences Co. Ltd, Beijing, 100081, China.
The construction of tunnels can easily trigger the reactivation of old landslide bodies, posing a threat to the transportation safety. In this study, using methods such as engineering geological investigation, slope deformation monitoring, deep displacement monitoring, and numerical simulation, the interaction between landslides and tunnels was investigated from the perspective of landslide deformation and failure characteristics. The Walibie Tunnel (WLBT) of Shangri-La to Lijiang (XL) expressway was taken as an example.
View Article and Find Full Text PDFComput Methods Biomech Biomed Engin
January 2025
Key Laboratory of Advanced Design and Simulation Techniques for Special Equipment, Ministry of Education, Hunan University, Changsha, China.
Total talus replacement has been demonstrated to increase ankle instability. However, no studies have explored how to enhance postoperative stability. This study aims to explore the effect of collateral ligament reconstruction on ankle stability by finite element analysis.
View Article and Find Full Text PDFCommun Biol
January 2025
Laboratoire de Chimie Bactérienne (LCB) Institut de Microbiologie, Bioénergies et Biotechnologie (IMM), Aix-Marseille Université-CNRS, UMR 7283, Marseille, France.
Cell movement on surfaces relies on focal adhesion complexes (FAs), which connect cytoskeletal motors to the extracellular matrix to produce traction forces. The soil bacterium Myxococcus xanthus uses a bacterial FA (bFA), for surface movement and predation. The bFA system, known as Agl-Glt, is a complex network of at least 17 proteins spanning the cell envelope.
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