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RNA nanotherapeutics for hepatocellular carcinoma treatment.
Theranostics
January 2025
Center for Nanomedicine and Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, particularly due to the limited effectiveness of current therapeutic options for advanced-stage disease. The efficacy of traditional treatments is often compromised by the intricate liver microenvironment and the inherent heterogeneity. RNA-based therapeutics offer a promising alternative, utilizing the innovative approach of targeting aberrant molecular pathways and modulating the tumor microenvironment.
View Article and Find Full Text PDFAI in Biomedicine-A Forward-Looking Perspective on Health Equity.
Int J Environ Res Public Health
December 2024
Department of Surgery, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI 96813, USA.
As new artificial intelligence (AI) tools are being developed and as AI continues to revolutionize healthcare, its potential to advance health equity is increasingly recognized. The 2024 Research Centers in Minority Institutions (RCMI) Consortium National Conference session titled "Artificial Intelligence: Safely, Ethically, and Responsibly" brought together experts from diverse institutions to explore AI's role and challenges in advancing health equity. This report summarizes presentations and discussions from the conference focused on AI's potential and its challenges, particularly algorithmic bias, transparency, and the under-representation of minority groups in AI datasets.
View Article and Find Full Text PDFNew Communication Technology and the Elderly: A Study on the Continuous Use of the Extreme Edition APP for Middle-Aged and Senior Citizens.
Behav Sci (Basel)
November 2024
School of Communication, Soochow University, Suzhou 215031, China.
Rapidly changing digital technologies are reconfiguring the way human society lives, indicating that more and more middle-aged and older adults will lead a digital life in the future. Whether digital technology for today can effectively improve the quality of digital life of this cohort is the focus of this study. This study proposed a "cognitive-emotional-behavioral" model and situated the use of the Extreme Edition App as a cross-sectional research object.
View Article and Find Full Text PDFMulti-Element Fingerprinting Combined with Chemometrics for Identification of Seaweeds and Innovative Risk-Benefit Assessment.
Foods
December 2024
State Key Laboratory of Drug Regulatory Science, National Institutes for Food and Drug Control, Beijing 100050, China.
Seaweeds are one of the major marine foods with high values. The diversity of seaweed species significantly impacts their quality and is closely linked to their purity and safety. For the first time, this study established a model to discriminate seaweed species using a multi-element fingerprinting approach for species identification.
View Article and Find Full Text PDFCTGCT, Centre of Excellence for the Technologies of Gene and Cell Therapy: Collaborative translation of scientific discoveries into advanced treatments for neurological rare genetic diseases and cancer.
Comput Struct Biotechnol J
December 2024
Centre for the Technologies of Gene and Cell Therapy, National Institute of Chemistry, Hajdrihova 19, SI1000 Ljubljana, Slovenia.
Article Synopsis
- The Centre of Excellence for the Technologies of Gene and Cell Therapy (CTGCT) has been established at the National Institute of Chemistry in Ljubljana, marking Slovenia’s first center dedicated to precision medicine and cutting-edge therapies.
- The CTGCT aims to advance cancer immunotherapy and personalized treatments for genetic diseases by developing innovative biomedical tools and collaborating with international institutions for effective therapy development.
- Its focus on translating research into practice, alongside partnerships with clinicians and patient organizations, positions the CTGCT as a key player in improving access to gene and cell therapies across Slovenia and the broader Eastern European region.
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