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Unlabelled: Gastritis cystica profunda (GCP) is a rare lesion of the stomach. It is characterised by hyperplasia and cystic dilation of the gastric gland in the submucosal layer. It is usually believed to occur at the site of previous gastric surgeries, as the anastomotic remnants act as a foundation for the development of the lesion.

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Gastritis cystica profunda (GCP) is a rare entity characterized by foveolar hyperplasia and cystic dilation of the gastric mucosa and submucosal glands. Its etiopathogenesis remains unknown. It has been associated with chronic inflammatory conditions, such as gastric surgery or bile reflux.

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Chronic active and atrophic gastritis as significant contributing factor to the development of gastric cystica profunda.

World J Gastroenterol

May 2024

Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, Budapest 1082, Hungary.

Article Synopsis
  • Gastric cystica profunda (GCP) is a rare gastric lesion with potential precancerous characteristics, making it a significant health concern.
  • GCP can develop due to chronic conditions like active and atrophic gastritis, as well as previous mucosal injuries from surgeries or biopsies.
  • The connection between GCP and early gastric cancers (EGCs) highlights the importance of careful examination and can be treated effectively through endoscopic resection.
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Gastritis cystica profunda presenting as an ulcerated lesion.

Dig Liver Dis

July 2024

Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, China. Electronic address:

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