Background: International normalized ratio (INR) derivation is dependent on the international sensitivity index (ISI) of thromboplastin. It varies with instrument and reagents used.
Objective: To evaluate the role of a correction factor in the derivation of INR.
Methods: We studied prothrombin time (PT) and INR from patients using 3 thromboplastins of varying ISI values. The correction factor was applied to the observed INR to obtain a corrected INR.
Results: The difference between corrected INR and observed INR values varies from -0.8 through 0.96.
Conclusions: Corrected INR is dependent on PT only. It can be applied to all patients irrespective of cause for elevated PT.
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| http://dx.doi.org/10.1093/labmed/lmx028 | DOI Listing |
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