AI Article Synopsis
- Blueberry leaves from various cultivars show inhibitory effects on adult T-cell leukemia (ATL) cell line growth, with a focus on seasonal variations.
- Extracts from 80% ethanol leaf samples were taken from different blueberry types (rabbit-eye, southern highbush, northern highbush, and wild) between April and December.
- The rabbit-eye blueberry leaves collected in December exhibited the strongest inhibition of ATL cell proliferation, indicating increased production of beneficial compounds prior to leaf fall.
Article Abstract
The inhibitory effects of blueberry leaves on the proliferation of adult T-cell leukemia (ATL) cell lines have previously been reported. A comparison of blueberry leaf extracts from different cultivars and seasonal variation were investigated regarding their effects on ATL cell line proliferation. The inhibitory effects of 80% ethanol leaf extracts from different blueberry cultivars collected from April to December in 2006 or 2008 were evaluated using two ATL cell lines. The bioactivities of leaf extracts of rabbit-eye blueberry ( Aiton; RB species), southern highbush blueberry ( spp.; SB species), northern highbush blueberry ( L.; NB species), and wild blueberry ( Thunb.; WB species) were compared. Of these, leaves of the RB species collected in December showed a significantly stronger inhibitory effect in both cell lines than the SB, NB, or WB species. These results suggest elevated biosynthesis of ATL-preventative bioactive compounds in the leaves of the RB species before the defoliation season.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532976 | PMC |
| http://dx.doi.org/10.3390/medicines1010003 | DOI Listing |
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