Aim Of The Study: To evaluate the anti-leishmanial activity and cytotoxicity of aqueous and organic extracts of ten plants used in Mexican traditional medicine as anti-parasitics.
Materials And Methods: For the organic extracts, plant material was macerated in dichloromethane (CHCl) and dichloromethane/methanol (CHCl/MeOH) (1:1) during two weeks; the aqueous extracts were prepared by infusion. The extracts were tested against promastigotes and intracellular amastigotes of . The cytotoxicity was assayed in parallel on peritoneal macrophages of BALB/c mice.
Results: Four of the thirty extracts tested were active and selective against promastigotes: (CHCl and CHCl/MeOH), (CHCl) and (aqueous). These extracts had a median inhibitory concentration (IC) against intracellular amastigotes under 50 μg/mL and a selectivity index (SI) higher than 5, which indicates that they constitute valuable candidates to obtain secondary metabolites with leishmanicidal activity.
Conclusions: The results derived from this study indicate that and might provide interesting new leads for the development of antileishmanial drugs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596308 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2017.e00394 | DOI Listing |
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