A three-step reaction sequence has been developed to prepare a variety of enantioenriched pyrroloisoquinoline derivatives. The process involves a catalytic asymmetric azomethine ylide 1,3-dipolar cycloaddition followed by an intramolecular Au-catalyzed alkyne hydroamination and enamine reduction.
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| http://dx.doi.org/10.1021/acs.joc.7b01927 | DOI Listing |
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