AI Article Synopsis
- LINE-1 (long interspersed nuclear elements) are retrotransposons that influence cancer cell growth and cell behavior, particularly in epithelial-mesenchymal transition.
- Recent studies show that LINE-1 is also involved in telomere maintenance, which is crucial for the survival of malignant cells.
- The findings highlight the broader role of LINE-1 in cell proliferation and suggest important implications for telomere evolution, embryonic development, and cancer treatment strategies.
Article Abstract
Long interspersed nuclear elements (LINE-1) are well known as retrotransposons. A number of reports indicate that down-regulation of LINE-1 substantially affects growth of malignant cells and epithelial mesenchymal transition, which is difficult to be explained by its function as retrotransposon. More recent data indicate that LINE-1 is broadly involved in the regulation of telomere maintenance. This explains the essential role of LINE-1 for survival of malignant cells and further supports a global function of active LINE-1 elements in cell proliferation. We further discuss the implications of LINE-1-associated telomere regulation on evolution of telomeric structures, on embryogenesis and on therapy of malignancies.
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| http://dx.doi.org/10.2741/4645 | DOI Listing |
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