Self-Assembly of Human Serum Albumin: A Simplex Phenomenon.

Biomolecules

Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G-1H9, Canada.

Published: September 2017

Spontaneous self-assemblies of biomolecules can generate geometrical patterns. Our findings provide an insight into the mechanism of self-assembled ring pattern generation by human serum albumin (HSA). The self-assembly is a process guided by kinetic and thermodynamic parameters. The generated protein ring patterns display a behavior which is geometrically related to a -simplex model and is explained through thermodynamics and chemical kinetics.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618250PMC
http://dx.doi.org/10.3390/biom7030069DOI Listing

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