AI Article Synopsis
- Pleomorphic lobular carcinoma in situ (PLCIS) is a rare type of lobular carcinoma in situ (LCIS) that was analyzed in 78 cases from 1998 to 2012.
- In this study, 60% of PLCIS cases were found to be associated with invasive carcinoma or ductal carcinoma in situ (DCIS) upon final surgical excision.
- The data suggests that when PLCIS is diagnosed through core needle biopsy, complete surgical excision is recommended due to a significant risk of upgrading to invasive forms of cancer.
Article Abstract
Pleomorphic lobular carcinoma in situ (PLCIS) of the breast is a rare variant of lobular carcinoma in situ (LCIS). We reviewed 78 cases of PLCIS diagnosed at our institution from 1998 to 2012. Among all cases, 47 (60%) were associated with invasive carcinoma and/or ductal carcinoma in situ (DCIS) after final surgical excision. Of the 20 cases with PLCIS alone on core needle biopsy (CNB), 6 (30%) were upgraded to invasive carcinoma or DCIS after final surgical excision. Our findings support a recommendation for complete surgical excision of PLCIS when diagnosed on CNB.
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| http://dx.doi.org/10.1111/tbj.12843 | DOI Listing |
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