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Chondroptotic chondrocytes in the loaded area of chondrocalcinotic cartilage: A clinical proposal?
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Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, 61029, Italy.
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Apoptosis
October 2014
DiSTeVA, Campus Scientifico Enrico Mattei, Università degli Studi di Urbino Carlo Bo, Via Ca' le Suore 2, 61029, Urbino, PU, Italy,
Chondrocyte death and loss of extracellular matrix are the central features in articular cartilage degeneration during osteoarthritis pathogenesis. Cartilage diseases and, in particular, osteoarthritis are widely correlated to apoptosis but, chondrocytes undergoing apoptosis "in vivo" more often display peculiar features that correspond to a distinct process of programmed cell death termed "chondroptosis". Programmed cell death of primary human chondrocyte has been here investigated in micromasses, a tridimensional culture model, that represents a convenient means for studying chondrocyte biology.
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