Endosome maturation requires a coordinated change in the Rab GTPase and phosphoinositide composition of the endosomal membrane. In this issue, Liu et al. (2017. https://doi.org/10.1083/jcb.201705151) identify WDR91 as a ubiquitous Rab7 effector that inhibits phosphatidylinositol 3-kinase activity on endosomes and is critical for endosome maturation, viability, and dendrite growth of neurons in vivo.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626559 | PMC |
| http://dx.doi.org/10.1083/jcb.201709034 | DOI Listing |
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