AI Article Synopsis
- Silk-elastin is a new recombinant protein polymer that combines silk and elastin to promote wound healing through a self-assembling process from liquid to gel.
- Researchers developed a silk-elastin sponge to address application challenges faced with the aqueous solution in clinical settings.
- The study found that the silk-elastin sponge effectively promotes granulation tissue formation just like the liquid version, as it dissolves in wound exudate to form a beneficial gel containing cytokines.
Article Abstract
Silk-elastin is a recombinant protein polymer with repeating units of silk and elastin blocks. This novel wound healing promoting material has the ability to self-assemble from a liquid to a gel. We have already reported that an aqueous solution of silk-elastin has the potential to accelerate wound healing; however, there are several problems in applying silk-elastin in the clinical setting. To solve these problems, we developed a silk-elastin sponge that is easy to use in the clinical setting. In the present study, we examined whether the wound healing effect of the silk-elastin sponge is equal to the aqueous solution of silk-elastin in vivo. The granulation tissue formation promoting effect of the silk-elastin sponge was equal to that of the aqueous solution the silk-elastin, as after application to the wound surface, the sponge was absorbed and dissolved by the exudate. At body temperature the silk-elastin then formed temperature gel. The silk-elastin gel that was obtained contained abundant cytokines from the exudate. We believe that silk-elastin sponge can be applied to various wounds that are difficult to treat with the aqueous solution.
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| http://dx.doi.org/10.1080/09205063.2017.1382829 | DOI Listing |
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