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Bipolar disorder in patients with psoriasis, and the impact of lithium therapy on psoriasis.
Clin Dermatol
January 2025
Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, RI, USA; GK Dermatology PC, South Weymouth, MA, USA.
Article Synopsis
- Research shows a connection between psoriasis and bipolar disorder (BD), with limited studies specifically addressing the link.
- The review analyzed various studies involving BD patients, lithium's effects on psoriasis, and found that psoriasis may increase the risk of developing BD.
- Lithium therapy might worsen psoriasis symptoms, but inositol supplementation could potentially alleviate these effects, highlighting the need for further investigation.
AIM2 deficiency in CD4 T cells promotes psoriasis-like inflammation by regulating Th17-Treg axis via AIM2-IKZF2 pathway.
J Autoimmun
January 2025
Department of Dermatology, the Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, China; Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu, China. Electronic address:
Psoriasis vulgaris remains a common inflammatory skin disease globally. The imbalance between Th17 and Treg cells plays an integral role in the pathogenesis of psoriasis vulgaris, but the underlying mechanisms remain obscure. The role of AIM2 in Treg cell function in psoriasis is unclear.
View Article and Find Full Text PDFSecukinumab-Aggravated Disseminated Discoid Lupus Erythematosus Misdiagnosed as Psoriasis.
Cureus
October 2024
Dermatology, Shanghai Skin Disease Hospital , Tongji University, Shanghai, CHN.
Discoid lupus erythematosus is an autoimmune disease. When the disease manifests in multiple sites, it is classified as disseminated discoid lupus erythematosus. It is challenging for dermatologists to distinguish this condition from other erythematous diseases, and it is sometimes misdiagnosed as psoriasis.
View Article and Find Full Text PDFAcrodermatitis continua of hallopeau: aggravating factors and treatment outcomes of 96 patients.
J Dermatolog Treat
December 2024
Dermatology Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Background: Acrodermatitis continua of Hallopeau (ACH) is a rare pustular psoriasis variant predominantly affects the distal phalanges of the fingers and toes. However, data on aggravating factors and treatment outcomes is limited.
Objective: This study aims to analyze the aggravating factors and treatment outcomes of ACH in a three-tertiary-hospital in South China.
Psoriasis and inflammatory bowel disease: concomitant IMID or paradoxical therapeutic effect? A scoping review on anti-IL-12/23 and anti-IL-23 antibodies.
Therap Adv Gastroenterol
November 2024
IBD Centre, Gastroenterology Unit, Rho Hospital, ASST Rhodense, Rho, Italy.
Inflammatory bowel diseases (IBD) and psoriasis are chronic inflammatory conditions belonging to the heterogeneous group of immune-mediated inflammatory diseases (IMIDs). A significant bidirectional link between these two entities has been observed, conditioning an increased risk of IBD in patients with psoriasis and vice-versa. Biological therapies used for IBD may lead to the occurrence of psoriasis as a "paradoxical reaction.
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