AI Article Synopsis
- Botulism is a serious infection that leads to muscle weakness and other serious symptoms, and recent studies show that cancer treatment might make individuals more susceptible to it.
- A 5-year-old boy undergoing chemotherapy for leukemia experienced muscle weakness and other symptoms, later diagnosed with botulism caused by Clostridium botulinum after multiple antibiotic treatments.
- This case reinforces the idea that children receiving cancer therapies are at a higher risk for botulism, emphasizing the need for awareness in immunocompromised patients.
Article Abstract
Background: Botulism is a potentially fatal infection characterized by progressive muscle weakness, bulbar paralysis, constipation and other autonomic dysfunctions. A recent report suggested that cancer chemotherapy might increase the risk for the intestinal toxemia botulism in both adults and children.
Case Presentation: We report a 5-year-old boy, who developed general muscle weakness, constipation, ptosis and mydriasis during the third induction therapy for relapsed acute myeloid leukemia. He had recent histories of multiple antibiotic therapy for bacteremia and intake of well water at home. Repeated bacterial cultures identified Clostridium botulinum producing botulinum neurotoxin A. Botulinum toxin A was isolated from his stools at 17, 21, and 23 days after the onset. Symptoms were self-limiting, and were fully recovered without anti-botulinum toxin globulin therapy.
Conclusion: This is the second report of a pediatric case with cancer chemotherapy-associated intestinal toxemia botulism. Our case provides further evidence that the immunocompromised status due to anti-cancer treatments increases the risk for the development of botulism at all ages in childhood.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604400 | PMC |
| http://dx.doi.org/10.1186/s12941-017-0240-y | DOI Listing |
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Article Synopsis
- Endotoxemia is linked to various diseases, and the gut microbiota plays a crucial role as it acts as a major reservoir of endotoxins in the body.
- Dysbiosis in the gut microbiota can lead to increased intestinal permeability and bacterial translocation, contributing to endotoxemia.
- The Mediterranean diet is highlighted as beneficial for gut health, potentially regulating the microbiota and supporting intestinal barrier function to mitigate endotoxemia.
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