Purpose: To evaluate the efficacy of a releasable single suture for pterygium excision with a conjunctival autograft (CAG).
Methods: Retrospective case series at a tertiary eye care center in central India was conducted. Medical records of 150 patients, who underwent primary pterygium excision with a CAG secured by a single releasable 10-0 nylon suture in the last year were reviewed. The surgical duration was noted. The suture was released on the first postoperative day under topical anesthesia. Patients were followed up until 1 year. At each visit, factors studied were patient comfort [pain grading on a visual analog scale], graft apposition, complications, and recurrence.
Results: Mean age of patients was 39 ± 11 years. Most patients in our study were female (58.7%). Sixty percent of pterygia were of Tan grade 2. The mean duration of surgery was 4.8 ± 1.3 minutes. The maximum size of the CAG was 6 mm (3-6 mm). The graft retraction rate was 5.3% (1 mm retraction in the CAG more than 5.5 mm) with no event of graft loss. Four percent of patients had grade 1 recurrence.
Conclusions: Releasable single suture may offer a good and simple alternative, which uses the gold standard technique of the CAG with exclusion of suture-related complications.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/ICO.0000000000001346 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Leveraging long-acting IL-15 agonists for intratumoral delivery and enhanced antimetastatic activity.
Front Immunol
November 2024
ProLynx Inc., San Francisco, CA, United States.
Article Synopsis
- IL-15 agonists are promising immunotherapy options as they boost the growth of immune cells like natural killer (NK) and CD8 T cells, but they have a short duration in the body requiring frequent doses.
- A new approach using hydrogel microspheres (MS) was developed to extend the half-life of IL-15, which successfully increased its duration to about one week.
- The study found that the MS conjugate of another IL-15 agonist, RLI, had a shorter half-life of 30 hours and was effective in stimulating immune cells, but caused significant injection-site toxicity; thus, it was focused on for intra-tumoral therapy where such effects could be potentially beneficial.
Developmental refinement of the active zone nanotopography and axon wiring at the somatosensory thalamus.
Cell Rep
October 2024
Division of Neurophysiology, Department of Physiology, School of Medicine, Tokyo Women's Medical University, Tokyo, Japan. Electronic address:
Functional refinement of neural circuits is a crucial developmental process in the brain. However, how synaptic maturation and axon wiring proceed cooperatively to establish reliable signal transmission is unclear. Here, we combined nanotopography of release machinery at the active zone (AZ), nanobiophysics of neurotransmitter release, and single-neuron reconstruction of axon arbors of lemniscal fibers (LFs) in the developing mouse somatosensory thalamus.
View Article and Find Full Text PDFReprocessing capabilities of newly approved devices for use in surgery.
Surgeon
October 2024
Division of Plastic and Reconstructive Surgery, Brigham and Women's Hospital, Harvard Medical School, USA.
Introduction: Single-use medical devices used in surgery can create environmental waste and increased costs. Reprocessed medical devices may reduce cost and environmental impact. This study investigated the reprocessing capabilities of newly FDA-approved devices in surgery.
View Article and Find Full Text PDFSpontaneous and evoked synaptic vesicle release arises from a single releasable pool.
Cell Rep
July 2024
Department of Cellular Biophysics, Institute of Medical Physics and Biophysics, University of Münster, Robert-Koch-Str. 31, 48149 Münster, Germany; Center for Soft Nanoscience SoN, University of Münster, Busso-Peus-Str.10, 48149 Münster, Germany; Cells in Motion Interfaculty Center, University of Münster, 48149 Münster, Germany. Electronic address:
The quantal content of an evoked postsynaptic response is typically determined by dividing it by the average spontaneous miniature response. However, this approach is challenged by the notion that different synaptic vesicle pools might drive spontaneous and evoked release. Here, we "silence" synaptic vesicles through pharmacological alkalinization and subsequently rescue them by optogenetic acidification.
View Article and Find Full Text PDFMutations of Single Residues in the Complexin N-terminus Exhibit Distinct Phenotypes in Synaptic Vesicle Fusion.
J Neurosci
July 2024
Charite - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Neurophysiology, 10117 Berlin, Germany
Article Synopsis
- The release of neurotransmitters at synapses relies on a series of protein interactions, particularly involving complexins, which play a role in regulating synaptic transmission.
- Research on the N-terminus of complexin II, focusing on its hydrophobic amino acids, shows that preserving this property supports its stimulatory function, while changes disrupt neurotransmitter release.
- Specific mutations in the N-terminus, particularly residue changes, can enhance spontaneous release but negatively affect evoked release, highlighting the importance of precise amino acid composition in managing synaptic neurotransmitter dynamics.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!