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Acceptability and feasibility of shared medical appointments to support self-management of anxiety and depression in primary care in England: a qualitative study of service user/patient perspectives.
BMJ Open
January 2025
School of Psychology, Newcastle University, Newcastle upon Tyne, UK
Objective: Shared medical appointments (SMAs) are an innovative care delivery method that provides delivery of clinical care while also supporting self-management. Their usefulness for mental health conditions has only briefly been explored, though early evidence demonstrates their utility for supporting mental health management. Therefore, this study set out to better understand the views that adults with anxiety and depression have towards SMAs as a way of receiving care to support self-management in primary care.
View Article and Find Full Text PDFThe Neuroendocrine Regulation of Reproductive Behavior and Emotional Control by Kisspeptin.
J Clin Endocrinol Metab
January 2025
Section of Endocrinology and Investigative Medicine, Imperial College London, London, United Kingdom.
Reproductive success and ultimately species survival at a population level is contingent on a plethora of neuroendocrine signals working in concert to regulate gonadal function and reproductive behavior. Among these, the neuropeptide kisspeptin (encoded by the KISS1/Kiss1 gene) has emerged as the master regulator of the hypothalamic-pituitary-gonadal axis. Besides the hypothalamus, both kisspeptin and its cognate receptor are extensively expressed throughout cortico-limbic brain structures in rodents and humans, which are regions traditionally implicated in behavioral and emotional responses.
View Article and Find Full Text PDFTreating Opioid Use Disorder and Opioid Withdrawal in the Context of Fentanyl.
Annu Rev Clin Psychol
January 2025
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; email:
The opioid crisis, driven by illicitly manufactured fentanyl, presents significant challenges in treating opioid use disorder (OUD) and opioid withdrawal syndrome. Fentanyl is uniquely lethal due to its rapid onset and respiratory depressant effects, driving the surge in overdose deaths. This review examines the limitations of traditional diagnostic criteria like those of the , Fifth Edition, Text Revision (DSM-5-TR) and explores the potential of dimensional models such as the Hierarchical Taxonomy of Psychopathology (HiTOP) for a more nuanced understanding of OUD.
View Article and Find Full Text PDFTemporal patterns of liver and adipose lipase abundance across the periparturient period in multiparous Holstein dairy cows.
JDS Commun
January 2025
Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706.
Lipases such as patatin-like phospholipase domain-containing protein 3 (PNPLA3) exist in multiple tissue types. In subcutaneous adipose tissue, PNPLA3 was not altered during the periparturient period. Conversely, strong associations between liver PNPLA3 and liver triglyceride content peripartum were identified and confirmed to be causative using knockdown approaches in a primary bovine hepatocyte model.
View Article and Find Full Text PDFActive control over exploration improves memory in toddlers.
Proc Biol Sci
January 2025
Department of Cognitive Science, Central European University, Vienna, Austria.
Across two experiments, we implemented a novel gaze-contingent eye-tracking paradigm to investigate the early emergence of memory benefits from active control over exploration and to examine how exploratory behaviours affect memory formation in early development. Toddlers (experiment 1: = 36, 18-36 months; experiment 2: = 41, 23-36 months) were either allowed to actively control their exploration (active condition) or presented with the same information that they could only passively observe (passive condition in experiment 1; yoked condition in experiment 2). They were then tested in a preferential-looking paradigm in which familiar versus novel stimuli were presented in pairs.
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