The effects of magnesium sulfate (MgSO) as a preanesthetic medication were studied with regard to whether it can sedate or relieve a patient who is scheduled to undergo surgery, and whether it can control the hemodynamic response to tracheal intubation. Twenty adult patients in ASA status 1-2 undergoing elective surgery were studied. Ten patients received 50 mg·g MgSO intravenously by drip infusion from 30 min before the induction of anesthesia, and another ten patients received saline as a control. The changes in mean arterial pressure (MAP) and rate pressure product (RPP) after the intubation were significantly suppressed in magnesium-treated patients, but a sedative effect was not observed. Therefore, MgSO was useful as a preanesthetic medication in suppressing the hemodynamic response associated with tracheal intubation.
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