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Physical exercise prevents age‐related changes in [C]PK11195 uptake in a mouse model of Down Syndrome.
Alzheimers Dement
December 2024
University of São Paulo Medical School, São Paulo, São Paulo, Brazil
Background: Down syndrome (DS) is associated with mitochondrial dysfunction leading to higher levels of oxidative stress and cell degeneration. This fact, together with the overexpression of AD‐related genes in trisomy 21, increases the risk of developing Alzheimer's disease (AD). Thus, it is important to look for interventions that could prevent mitochondrial damage before symptoms occur.
View Article and Find Full Text PDFHygienic behaviors and use of dental care in patients with genetic syndromes.
Sci Rep
December 2024
Department of Paediatric Dentistry, Medical University of Warsaw, St. Binieckiego 6, 02-097, Warsaw, Poland.
Patients with genetic syndromes require special dental attention because they have symptoms that promote plaque accumulation, dental erosion, dental caries and gingival diseases. The aim of the study was to assess hygienic behaviors, use of dental care and frequency of professional preventive procedures among Polish children and adolescents with Prader-Willi, Down, Angelman, Silver-Russell and Smith-Lemli-Opitz syndromes. Parents/legal guardians of children and adolescents with genetic syndromes were included.
View Article and Find Full Text PDFEssential role of sulfide oxidation in brain health and neurological disorders.
Pharmacol Ther
December 2024
Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address:
Hydrogen sulfide (HS) is an environmental hazard well known for its neurotoxicity. In mammalian cells, HS is predominantly generated by transsulfuration pathway enzymes. In addition, HS produced by gut microbiome significantly contributes to the total sulfide burden in the body.
View Article and Find Full Text PDFGlobal Prevalence of Duodenal Atresia in Trisomy 21: A Systematic Review and Meta-Analysis.
Eur J Pediatr Surg
December 2024
Department of Surgery and Anesthesia, School of Medicine, Mu'tah University, Mu'tah, Karak, Jordan.
Introduction: Duodenal atresia is one of significant causes of neonatal intestinal obstruction. It often co-occurs with Down syndrome. This study is conducted to estimate the global prevalence of duodenal atresia in Down syndrome patients and to investigate associated factors.
View Article and Find Full Text PDFExamination of Core Clinical Symptoms of Postoperative Fatigue Syndrome Following Colonoscopy With Sedation.
J Perianesth Nurs
December 2024
Department of Anesthesiology, Northern Jiangsu People's Hospital, Yangzhou, China. Electronic address:
Article Synopsis
- - The study aimed to identify and categorize discomfort symptoms following sedative-administered colonoscopy, with the goal of developing criteria to recognize postoperative fatigue syndrome (POFS).
- - Researchers conducted follow-up interviews with 542 patients who had undergone the procedure to collect data on 19 different discomfort symptoms, including fatigue, lethargy, and dizziness.
- - The key findings suggest that the main symptoms defining POFS are fatigue, lethargy, dizziness, and headache, which should be included in diagnostic criteria for this syndrome.
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