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Commercialisation fears and preferred forms of governance: a mixed methods investigation to identify a trusted Australian genomics repository.
Front Public Health
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Melbourne Law School, The University of Melbourne, Parkville, VIC, Australia.
This study aimed to identify operating conditions and governance mechanisms that would help to facilitate trust in, and willingness to donate to, a hypothetical Australian national genomic repository for health research where commercial use of data is permitted. Semi-structured telephone interviews with members of the Australian public ( = 39) clarified perceived risks and preferred repository conditions. These insights were subsequently tested experimentally in a national sample ( = 1,117).
View Article and Find Full Text PDFPredicting Mutations in Cutaneous Melanoma Patients Using Neural Network Analysis.
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Scientific Department, Medical Laboratory CSD, Kyiv, Ukraine.
Point mutations at codon 600 of the BRAF oncogene are the most common alterations in cutaneous melanoma (CM). Assessment of BRAF status allows to personalize patient management, though the affordability of molecular testing is limited in some countries. This study aimed to develop a model for predicting alteration in BRAF based on routinely available clinical and histological data.
View Article and Find Full Text PDFNeed for and update on clinical trials for uncomplicated type B aortic dissection.
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January 2024
Academic Department of Vascular Surgery, South Bank Section, School of Cardiovascular and Metabolic Medicine and Sciences, King's College London, British Heart Foundation Centre of Research Excellence, St Thomas' Hospital, London, UK.
The mainstay of management for uncomplicated type B aortic dissection is currently optimal medical therapy, targeting blood pressure and heart rate, along with serial imaging. There is a paucity of data that informs whether early intervention with thoracic endografting in this group of patients will promote aortic remodeling and better long-term outcomes. Investigations to date, including the Investigation of Stent Grafts in Aortic Dissection (INSTEAD), INSTEAD-XL, and Acute Dissection: Stent Graft or Best Medical Therapy (ADSORB) studies, have compared thoracic endovascular aortic repair (TEVAR) with optimal medical therapy in patients with uncomplicated type B aortic dissection but have not shown a benefit for TEVAR conclusively.
View Article and Find Full Text PDFRetention strategies for medical doctors in low- and middle-income countries (LMICs): are they effective? A scoping review.
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Centre of Leadership and Professional Development, Institute for Health Management, National Institutes of Health, Ministry of Health Malaysia, Shah Alam, Selangor, Malaysia.
Background: High turnover among the medical professions is detrimental to the healthcare system and population well-being, particularly in low- and middle-income countries (LMICs) with limited financial and human resources. To prevent brain drain, effective strategies are vital to improve the retention of healthcare workers, especially doctors. However, little evidence has been synthesised regarding the effectiveness of these strategies, especially in LMICs.
View Article and Find Full Text PDFThe association between nutrition risk status assessment and hospital mortality in Chinese older inpatients: a retrospective study.
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Department of Nursing, Changde Hospital, Xiangya School of Medicine, Central South University（The first people's hospital of Changde city), Changde, Hunan Province, China.
Purpose: The association between nutritional risk status assessment and hospital mortality in older patients remains controversial. The aim of this study was to assess the relationship between nutritional risk on admission and in-hospital mortality, and explore the best Nutritional Risk Status Screening 2002 (NRS2002) threshold for predicting in-hospital mortality of older inpatients in China.
Method: The elderly inpatients were recruited from a hospital in Hunan Province, China.
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