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http://dx.doi.org/10.1016/j.omtn.2017.08.008 | DOI Listing |
J Biochem Mol Toxicol
December 2024
Department of Urology, Shaoxing People's Hospital, Shaoxing, China.
Prostate cancer (PCa) is one of the leading causes of cancer death among men worldwide. Circular RNAs (circRNAs) have been implicated in the pathogenesis of PCa. However, the precise action of circ_0001326 in PCa malignant progression is still unknown.
View Article and Find Full Text PDFInt Immunopharmacol
December 2024
Xinjiang Medical University, School of Basic Medical Science, Urumqi 830017, China; Key Laboratory of Forensic Medicine, School of Basic Medical Sciences, Xinjiang Medical University, China; Department of Discipline Construction, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China. Electronic address:
Biomolecules
October 2024
National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
Mitochondria serve as central hubs for regulating numerous cellular processes that include metabolism, apoptosis, cell cycle progression, proliferation, differentiation, epigenetics, immune signaling, and aging. The voltage-dependent anion channel 1 (VDAC1) functions as a crucial mitochondrial gatekeeper, controlling the flow of ions, such as Ca, nucleotides, and metabolites across the outer mitochondrial membrane, and is also integral to mitochondria-mediated apoptosis. VDAC1 functions in regulating ATP production, Ca homeostasis, and apoptosis, which are essential for maintaining mitochondrial function and overall cellular health.
View Article and Find Full Text PDFFree Radic Biol Med
November 2024
Department of Orthopaedics, The First Affiliated Hospital of Jinan University, No. 613 11 West Huangpu Avenue, Tianhe District, Guangzhou, Guangdong, 510630, China.
Rationale: Difficulty in skin wound healing is a concern for diabetic patients across the world. Impaired mitochondrial dysfunction and aging-related vascular dysfunction in human umbilical vein endothelial cells (HUVECs) caused by oxidative stress are major impediments to diabetic wound healing. However, research on skin repair at the mechanistic level by improving mitochondrial function and inhibiting oxidative stress-induced HUVEC senescence remains lacking.
View Article and Find Full Text PDFCancers (Basel)
August 2024
Department of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.
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