Electro-mediated microextraction (EMM) combined with micro-high performance liquid chromatography-ultraviolet detection was successfully developed for the determination of selected phenols, namely 4-chlorophenol (4CP), 2-nitrophenol (2NP) and 2,4-dichlorophenols (2,4 DCP) in water. A solvent-impregnated agarose gel disc was utilized as a solvent holder in this study. Under optimum extraction conditions, the method showed good linearity in the range of 0.1-250µgL, 0.3-250µgL and 0.2-500µgL for 4CP, 2NP and 2,4 DCP, respectively with correlation coefficients of ≥ 0.9975, ultra-trace LODs (0.03-0.1µgL) and satisfactory relative recovery average (85.0-114.1%) for the analysis of selected phenols. The proposed method was rapid and eco-friendly as the solvent holder was constructed using minute amounts of extraction solvent immobilized within the biodegradable agarose gel disc. A comparative microextraction technique termed solvent-impregnated agarose gel liquid phase microextraction (AG-LPME) was re-optimized and validated for the extraction of phenols in water. The method offered good linearity, ultra-trace LODs ranging 0.1-0.5µgL and satisfactory average of relative recovery (86.1-114.1%). The EMM was superior in terms of sensitivity and time-effectiveness compared to AG-LPME. Both techniques combine extraction and pre-concentration in mini-scaled approaches using an eco-friendly solvent holder that fulfil the green chemistry concept.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.talanta.2017.08.068 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sex-associated differences in incentive salience and drinking behaviour in a rodent model of alcohol relapse.
Addict Biol
January 2025
Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
The ability of environmental cues to trigger alcohol-seeking behaviours is thought to facilitate problematic alcohol use. Individuals' tendency to attribute incentive salience to cues may increase the risk of addiction. We sought to study the relationship between incentive salience and alcohol addiction using non-preferring rats to model the heterogeneity of human alcohol consumption, investigating both males and females.
View Article and Find Full Text PDFModeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis.
J Vis Exp
November 2024
Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois Chicago;
Two-bottle choice home cage drinking is one of the most widely used paradigms to study ethanol consumption in rodents. In its simplest form, animals are provided with access to two drinking bottles, one of which contains regular tap water and the other ethanol, with daily intake measured by change in bottle weight over the 24 h period. Consequently, this approach requires no specialized laboratory equipment.
View Article and Find Full Text PDF3D Printed Coated Blade Spray-Mass Spectrometry Devices.
Anal Chem
October 2024
Department of Chemistry, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada.
Article Synopsis
- - Coated blade spray-mass spectrometry (CBS-MS) is a technique for quickly detecting small amounts of target compounds in complex biological mixtures, but its use is limited due to the lack of accessible MS interfaces and extraction tools.
- - This research introduces new CBS-MS solutions made with 3D printing, including a flexible mass spectrometry interface and two extraction devices designed for large samples and single-drop blood, improving efficiency and reducing contamination risks during the analysis.
- - The new devices were effective in screening for seven drugs in urine and blood samples, with rapid sample preparation times, while also addressing potential contamination issues from 3D-printed materials.
Ultra-Long-Term Delivery of Hydrophilic Drugs Using Injectable Cross-Linked Depots.
bioRxiv
August 2024
Harvard Medical School, Boston, MA, USA.
Article Synopsis
- Achieving ultra-long-term release of hydrophilic drugs (over six months) poses a challenge for existing long-acting injectables (LAIs), which often face issues like burst release and rapid drug diffusion due to their design.
- A new injectable platform called ISCD, created using a methacrylated ultra-low molecular weight pre-polymer (polycaprolactone), addresses these issues by minimizing burst release and controlling water exchange through a dense mesh network.
- Studies show that ISCD successfully delivers various hydrophilic drugs (including antiretrovirals and antibiotics) and enables co-delivery of multiple drugs, with the potential for improved adherence in chronic conditions while surpassing the one-month drug release standard of existing LA
Streamlined integrated protein isoelectric focusing using microfluidic paper-based device.
J Chromatogr A
September 2024
Chimie ParisTech, PSL University, CNRS 8060, Institute of Chemistry for Life and Health Sciences, 75005 Paris, France. Electronic address:
An innovative integrated paper-based microdevice was developed for protein separation by isoelectric focusing (IEF), allowing for robust design thanks to a 3D-printed holder integrating separation channel, reservoirs, and electrodes. To reach robustness and precision, the optimization focused on the holder geometry, the paper nature, the reservoir design, the IEF medium, and various focusing parameters. A well-established and stable pH gradient was obtained on a glass-fiber paper substrate with simple sponge reservoirs, and the integration of the electrodes in the holder led to a straightforward system.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!